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TDI 028 (aks TDI-846) may protect motor nerves from further deterioration by reducing inflammation. A monoclonal antibody directed against CD40 ligand, TDI 0028 downregulates the T co-stimulatory pathway, reducing the production of pro-inflammatory cytokines that destroy the motor nerves. CD40 ligand blockers are being developed for a number of conditions including arthritis, multiple sclerosis and cancer.

Isolated originally from the roots of Canadian hemp, apocynin may protect motor nerves from further deterioration by reducing production of damaging reactive oxygen species. Apocynin is also being investigated as a treatment for respiratory diseases such as asthma.

Arimoclomol may reduce the levels of protein aggregates in the motor nerves, a possible cause of ALS, by boosting expression of chaperonins Hsp70 and Hsp90 which help newly synthesized proteins properly fold.