Clinical Trials

With no effective ALS treatments currently available to slow or stop the disease, many ALS patients opt to participate in clinical trials. ALS TDI provides unbiased and up-to-date information about ALS clinical trials taking place worldwide. Search our database by type and category to find and compare trials. Input your zip code to find clinical trials closest to you. Click here to learn more about the clinical trial process >

Active Trials

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Last Updated Trial Phase Recruiting Sponsor Location(s)
Within a Month
8/25/2014 Phase 3 Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis III Ongoing, But Not Recruiting Mitsubishi Tanabe Pharma Corporation
8/25/2014 Safety Study of VM202 to Treat Amyotrophic Lateral Sclerosis I/II Currently Recruiting ViroMed Co., Ltd. (VM BioPharma) Chicago, IL, US
8/22/2014 Mexiletine for the Treatment of Muscle Cramps in ALS IV Currently Recruiting Bjorn Oskarsson, MD Sacramento, CA, US
Chester, CA, US
View all 6 locations
8/22/2014 Dose Escalation and Safety Study of Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis II Ongoing, But Not Recruiting Neuralstem Inc. Ann Arbor, MI, US
Atlanta, GA, US
View all 3 locations
8/18/2014 Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study of Autologous MSC-NTF Cells in Patients With ALS II Currently Recruiting Brainstorm-Cell Therapeutics Boston, MA, US
Worcester, MA, US
View all 3 locations
8/11/2014 A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy I Currently Recruiting Mayo Clinic Rochester, MN, US
8/8/2014 Mexiletine in Sporadic Amyotrophic Lateral Sclerosis (SALS) II Ongoing, But Not Recruiting University of Washington Boston, MA, US
Dallas, TX, US
View all 10 locations
8/8/2014 Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive FALS II/III Ongoing, But Not Recruiting University of Miami Boston, MA, US
Miami, FL, US
8/5/2014 Clinical Trial Nuedexta in Subjects With ALS II Currently Recruiting Center for Neurologic Study Cleveland, OH, US
Grand Rapids, MI, US
View all 7 locations
Within 6 Months
7/31/2014 Immunosuppression in Amyotrophic Lateral Sclerosis (ALS) II Currently Recruiting Emory University Atlanta, GA, US
Boston, MA, US
View all 3 locations
7/22/2014 Biological Treatment of Amyotrophic Lateral Sclerosis I Currently Recruiting Pomeranian Medical University Szczecin Szczecin, Poland
6/19/2014 Tamoxifen Treatment in Patients With Motor Neuron Disease Phase I/II Currently Recruiting Taipei Medical University Shuang Ho Hospital New Taipei City, Taiwan
6/17/2014 Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation (RespiStimALS) III Currently Recruiting Assistance Publique - Hôpitaux de Paris Paris, France
6/16/2014 SOD1 Inhibition by Pyrimethamine in Familial ALS I/II Ongoing, But Not Recruiting Weill Medical College of Cornell University Houston, TX, US
New York, NY, US
View all 5 locations
6/16/2014 A Study of E0302 II/III Ongoing, But Not Recruiting Eisai Limited Chiba, Japan
Aichi, Japan
View all 44 locations
6/4/2014 Oral Nutritional Supplementation in Amyotrophic Lateral Sclerosis (ALS) Patients Not Yet Recruiting University Hospital, Limoges Limoges, France
6/3/2014 Humanitarian Device Exemption Post-Approval Study of NeuRx Diaphragm Pacing System Currently Recruiting Synapse Biomedical San Francisco, CA, US
Los Angeles, CA, US
View all 11 locations
5/28/2014 Diaphragm Pacing System (DPS) In Participants With Amyotrophic Lateral Sclerosis (ALS) II Currently Recruiting State University of New York - Upstate Medical University Boston, MA, US
Columbus, OH, US
View all 24 locations
5/6/2014 Therapy in Amyotrophic Lateral Sclerosis With Memantine at 20 mg BID (TAME) II Currently Recruiting Phoenix Neurological Associates, LTD Phoenix, AZ, US
Orange County, CA, US
View all 8 locations
5/6/2014 Rasagiline in Subjects With Amyotrophic Lateral Sclerosis (ALS) II Currently Recruiting Richard Barohn, MD Dallas, TX, US
Philadelphia, PA, US
View all 10 locations
4/18/2014 Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase I-II Study of Safety and Activity of Low Dose Interleukin-2 Phase I, Phase II Not Yet Recruiting Centre Hospitalier Universitaire de Nīmes Montpellier, France
Nîmes Cedex 9, France
4/14/2014 Gilenya in Amyotrophic Lateral Sclerosis (ALS) II Currently Recruiting Massachusetts General Hospital Augusta, GA, US
Boston, MA, US
View all 4 locations
4/8/2014 A Study to Explore the Safety and Tolerability of Acthar in Patients With Amyotrophic Lateral Sclerosis II Ongoing, But Not Recruiting Questcor Pharmaceuticals, Inc. Atlanta, GA, US
Boston, MA, US
View all 21 locations
4/2/2014 Study of Ozanezumab (GSK1223249) Versus Placebo in the Treatment of Amyotrophic Lateral Sclerosis II Ongoing, But Not Recruiting GlaxoSmithKline Boston, MA, US
Columbus, OH, US
View all 35 locations
Within a Year
2/18/2014 A Long-Term Study of E0302 II/III Ongoing, But Not Recruiting Eisai Limited Yamaguchi, Japan
Hokkaido, Japan
View all 42 locations
2/6/2014 Autologous Cultured Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in Patients With Amyotrophic Lateral Sclerosis (ALS) IIA Ongoing, But Not Recruiting Hadassah Medical Organization Jerusalem, Israel
1/29/2014 Study of Rasagiline in Patients With Amyotrophic Lateral Sclerosis II Currently Recruiting University of Ulm Berlin, Germany
Bochum, Nordrhein-Westfalen, Germany
View all 15 locations
1/29/2014 A Clinical Trial of Safety and Efficacy of Fasudil in Subjects With Amyotrophic Lateral Sclerosis (ALS) II Currently Recruiting Peking University Third Hospital Beijing, China
1/29/2014 Evaluation of Masitinib in Amyotrophic Lateral Sclerosis III Currently Recruiting AB Science Madrid, Spain
1/27/2014 Clinical Trial of Vitamin E to Treat Muscular Cramps in Patients With ALS III Currently Recruiting Lawson Health Research Institute London, Canada
1/27/2014 Olanzapine for the Treatment of Amyotrophic Lateral Sclerosis (ALS) Cachexia II/III Currently Recruiting Charite University, Berlin, Germany Berlin, Germany
1/27/2014 Cistanche Total Glycosides (CTG) II Currently Recruiting Peking University Beijing, China
1/27/2014 Safety and Tolerability of Anakinra in Combination With Riluzol in ALS II Currently Recruiting Charite University, Berlin, Germany Berlin, Germany
1/27/2014 Nocturnal PtcCO2 Monitoring in Patients With ALS Currently Recruiting Association Nationale pour le Traitement à Domicile de l'Insuffisance Respiratoire Lille, France
1/27/2014 Human Neural Stem Cell Transplantation in ALS (hNSCALS) I Currently Recruiting Azienda Ospedaliera Santa Maria Italy
1/27/2014 DiPALS Diaphragm Pacing in MND N/A Currently Recruiting Sheffield Teaching Hospitals NHS Trust Plymouth, United States
Leeds, United Kingdom
View all 7 locations
1/27/2014 Incobotulinum Toxin A (Xeomin) for Troublesome Sialorrhea II Currently Recruiting Beth Israel Deaconess Medical Center Boston, MA, US
1/27/2014 Transcranial Direct Current Stimulation II Currently Recruiting Università degli Studi 'G. d'Annunzio' Chieti e Pescara Italy
1/27/2014 Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis I Currently Recruiting Hanyang University Seoul Hospital Seoul, South Korea
1/24/2014 Aerobic Exercise Training Currently Recruiting Fondazione Salvatore Maugeri Italy
1/24/2014 Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS) I Currently Recruiting Johns Hopkins University Baltimore, MD, US
Charlestown, MA, US
View all 4 locations
1/24/2014 Determining the Safety of L-serine in ALS Phase I & II Currently Recruiting Phoenix Neurological Associates, LTD Phoenix, AZ, US
1/24/2014 Toxin Treatment for ALS-Related Sialorrhea (ALS-TOX) II Currently Recruiting Hospices Civils de Lyon France
France
View all 15 locations
1/8/2014 Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of ALS I Ongoing, But Not Recruiting Neuralstem Inc. Atlanta, GA, US
12/5/2013 A Safety Study of sNN0029 Administration Via Intracerebroventricular Route to Patients With Amyotrophic Lateral Sclerosis I Not Yet Recruiting NeuroNova AB Leuven, Belgium
Utrecht, Netherlands
11/5/2013 A Study of the Safety and Tolerability of Tocilizumab in ALS II Not Yet Recruiting ALS Association Kansas City, KS, US
Los Angeles, CA, US
View all 3 locations
10/11/2013 Dysfunctions and Plasticity Mechanisms of Motor System Assessed by Cortico-cortical and Cortico-muscular Coherence Analysis in Amyotrophic Lateral Sclerosis Ongoing, But Not Recruiting Assistance PubliqueHopitaux de Marseille Marseille, France
9/23/2013 The Use of Autologous Bone Marrow Stem Cells in ALS (Extension CMN/ELA) I/II Ongoing, But Not Recruiting Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia El Palmar, Spain
More Than a Year
3/27/2013 Trial of Safety and Efficacy of Rasagiline in Patients With ALS II Ongoing, But Not Recruiting University of Kansas Kansas City, KS, US
Philadelphia, PA, US
View all 3 locations
3/27/2013 Polysomnography-directed Noninvasive Ventilation in ALS Ongoing, But Not Recruiting Columbia University New York, NY, US
3/27/2013 Muscle Training of Patients with ALS (ALS-project) Currently Recruiting University of Southern Denmark Denmark
3/27/2013 Study of Creatine Monohydrate in Patients With ALS III Ongoing, But Not Recruiting The Avicena Group Albuquerque, NM, US
Charlotte, NC, US
View all 8 locations
3/27/2013 Motor-Point Stimulation for Conditioning the Diaphragm of Patients With ALS Ongoing, But Not Recruiting Synapse Biomedical Baltimore, MD, US
Cleveland, OH, US
View all 8 locations
3/27/2013 A Multi-Center Controlled Screening Trial of Safety and Efficacy of Lithium Carbonate in Subjects II Ongoing, But Not Recruiting Forbes Norris MDA/ALS Research Center Houston, TX, US
Kansas City, KS, US
View all 10 locations
3/27/2013 Efficacy and Tolerability of Tauroursodeoxycholic Acid (TUDCA-ALS) II Ongoing, But Not Recruiting Istittuto Nazionale Neurologico Carlo Besta Milan, Italy
3/27/2013 Efficacy and Safety of YAM80 II Ongoing, But Not Recruiting Yoshino Neurology Clinic Tokyo, Japan

I choose to participate in a trial for multiple reasons:

  1. PALS desperately need an effective treatment. There are multiple promising drugs, currently. But, the only way to obtain FDA approval is via proving safety and efficacy in human clinical trials. So, I chose to participate to advance the pursuit of an effective therapy.
  2. Though trials are not intended for treatment of participants, this is a large motivating factor. Most trials have at least a 50% chance of affecting disease progression or duration. But even if one ends up on a placebo arm, they are serving an important role.
  3. When presented with an opportunity to choose among multiple trials, I think of it as similar to an election, and choose the trial I believe holds the most promise for resulting in approval of the most effective therapy. There are too few participants, so I believe choosing "just any trial" can inadvertently slow progress towards effective therapies.

What is participation like? To me participation is very similar to a combination of frequent ALS clinic visits with lab work and of course with the addition of taking a drug.

-Rob (North Carolina)