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Isolated originally from the roots of Canadian hemp, apocynin may protect motor nerves from further deterioration by reducing production of damaging reactive oxygen species. Apocynin is also being investigated as a treatment for respiratory diseases such as asthma.

Arimoclomol may reduce the levels of protein aggregates in the motor nerves, a possible cause of ALS, by boosting expression of chaperonins Hsp70 and Hsp90 which help newly synthesized proteins properly fold.