Creatine may slow the progression of ALS by boosting energy supplies to weakening muscles and deteriorating motor nerves. A metabolic supplement, many atheletes take creatine to increase muscle strength.
We think that creatine may be moderately beneficial in people with ALS.
This section will be populated with information from TDI over the coming weeks and months. It will include rationales for screening these candidate therapeutic in our lab and the results from those experiments. More info here.
Creatine did not significantly improve function or survival according to 3 trials of 386 patients.
Creatine appears safe but ineffective in a double-blind placebo-controlled trial of 104 ALS patients...
Creatine appears safe and efficiently crosses the blood brain barrier in a trial of 6 patients.
Creatine and celecoxib merit further evaluation as a potential combinatorial therapy for ALS.
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