Dexpramipexole

Highly related to the Parkinson’s disease drug pramipexole (Mirapex), the neuroprotectant dexpramipexole (Empower) may slow the progression of ALS by keeping the power on in deteriorating motor nerves. Dexpramipexole is thought to maintain mitochondrial function in people with ALS by detoxifying reactive oxygen and nitrogen species.

Status
Type:	Small Molecule
Status:	Phase III
Sponsor:	Biogen Idec

TDI Says:

“The results from the phase II clinical trial suggest that dexpramipexole is extremely promising. We look forward to the outcome of the ongoing phase III trial.”

Our Work on Dexpramipexole

There is no internal work posted

Other Published Results

The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis.

ALS progressed 31% slower in patients taking 300mg of dex daily for 12 weeks than those on placebo.

Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects.

Dexpramipexole appears safe and well-tolerated in two phase I clinical trials of 54 healthy adults.

R+ pramipexole as a mitochondrially focused neuroprotectant: initial early phase studies in ALS.

Dex exhibits fewer side effects than pramipexole according to an open label trial of 10 ALS patients...

ALS Today Magazine Articles

Empower Gathers Steam

Dexpramipexole shows promise as a treatment for ALS according to phase II results published this week.

ALS, More Than A Power Play

A new study revisits the debate about whether defects in mitochondria – the putative target of dexpramipexole – cause ALS.

ALS, Off The Beaten Track

Emerging ALS mitochondrial-targeted medicines such as dexpramipexole are gathering steam. But, these medicines may need to do a lot more than boost energy production to stop the disease.

Forum Discussion

Forum posts do not necessarily reflect TDI opinion.

DISCUSSION TITLE	POSTS	LAST ACTIVE
So.. this Phase III KNS trial -- when's it happening?	6	4/17/2010

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Mitochondrial Dysfuntion

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