Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS)

Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS)

Quick Info:

Status:
Currently Recruiting
Estimated Enrollment:
60
Phase:
I
Treatment Type:
Exercise
Trial Type:
Sponsor:
Johns Hopkins University
Primary Investigator:
Contact Information:

Enrollment Criteria:

Forced Ventilation

Breathing Ability

Percent lung function (FVC) or (SVC)
≥70%
Months/Onset

Months Since Onset

Number of months since first
symptoms of ALS
<60
BiPap Allowed

Non-Invasive Ventilation (NIV)

Can PALS use a BiPAP in the trial?
Unknown
DPS Allowed

Diaphragm Pacer (DPS)

an PALS use a DPS in the trial?
Unknown

Update Notes:

5/27/2015No significant updates.
1/24/2014Recruitment status updated
11/4/2013Now recruiting people participating in certain clinical trials including tirasemtiv.
4/10/2013Location information updated.
3/27/2013Enrollment criteria added.

Locations:

Johns Hopkins University, Baltimore, 21287
Massachusetts General Hospital, Charlestown, 02129
Carolinas Medical Center, Charlotte, 28207
Washington University, St. Louis, 63110

Other Information:

Purpose: This study will help in the development of a larger national study to understand how exercise can be combined with other treatments to potentially improve strength and alter the course of the disease.
Eligibility: 18 - 80 yrs with possible, laboratory-supported probable, probable, or definite ALS
Details: Patients will exercise for 6 months using a clinical prescribed weightlifting, stationary bicycling or stretching/range of motion routine.
Collaborator(s):
ALS Forum:
First Published on Clinicaltrials.gov: 1/24/2012
ClinicalTrials.gov ID: NCT01521728
Trial Protocol as Published on Clinicaltrials.gov:
ClinicalTrials.gov