Mexiletine for the Treatment of Muscle Cramps in ALS

Mexiletine for the Treatment of Muscle Cramps in ALS

Quick Info:

Status:
This study has been completed
Estimated Enrollment:
30
Phase:
IV
Treatment Type:
Capsule
Trial Type:
Double blind placebo
Sponsor:
Bjorn Oskarsson, MD
Primary Investigator:
Contact Information:

Enrollment Criteria:

Forced Ventilation

Breathing Ability

Percent lung function (FVC) or (SVC)
N/A
Months/Onset

Months Since Onset

Number of months since first
symptoms of ALS
N/A
BiPap Allowed

Non-Invasive Ventilation (NIV)

Can PALS use a BiPAP in the trial?
Yes
DPS Allowed

Diaphragm Pacer (DPS)

an PALS use a DPS in the trial?
Yes

Update Notes:

5/12/2016Recruitment status updated.
1/20/2016Recruitment status updated.
12/3/2015Collaborator added.
5/27/2015No significant updates.
10/17/2014Enrollment criteria updated, Recruitment status update.
8/22/2014No significant updates
6/25/2014New locations added.
2/3/2014No significant updates.
1/27/2014New location added.
5/14/2013Protocol updated.
5/13/2013Enrollment criteria updated.
3/27/2013Enrollment criteria added.
3/26/2013Description updated.
3/14/2013Clinical trial added.

Locations:

UC, Davis Medical Center ALS Clinic, Sacramento, 95817
UCD Telehealth Network Lake Almanor Clinic, Chester, 96020
UCSD Department of Neurosciences ALS Clinical Tria, La Jolla, 92093
UCLA Neuromuscular Research Program, Los Angeles, 90095
UCD Telehealth Network
UC Irvine Health ALS & Neuromuscular Center, Orange, 92868

Other Information:

Purpose: The purpose of this study is to determine if mexiletine is effective for the treatment of muscle cramps in Amyotrophic Lateral Sclerosis (ALS).
Eligibility: both genders 21-89, no healthy volunteers, life expectancy >6 months, see protocol
Details: Many ALS patients suffer from painful muscle cramps, but unfortunately we do not have any medication proven to help muscle cramps in ALS. Reducing the pain caused by cramps - which can be debilitating - could help people living with ALS. Muscle cramps are sudden, painful, and involuntary contractions of a muscle. They are caused by nerve dysfunction. When we examine nerves and muscles electrically, we see cramps as bursts of high-frequency (up to150 Hz) firing of the motor nerve cells. Cramps in ALS are believed to be the result of an increase of persistent sodium currents in the sick lower motor nerve cells. A medication called Quinine was for many years the commonly used drug for controlling cramps in ALS, but the FDA has advised against its use for cramps because of its potential risks (e.g., death). Today there is no agreement on how to treat cramps in the ALS. The American Academy of Neurology recently encouraged further studies of the treatment of muscle cramps and suggested lidocaine as one of a few drugs of special interest. Mexiletine: Mexiletine is a medication closely related to lidocaine that can be taken by mouth (instead of being injected). Mexiletine stops the type of sodium currents that are thought to cause muscle cramps. Mexiletine is a relatively older medication that has been extensively studied in humans. It has been shown to reduce the electrical measures of muscle cramps for other disease conditions. For example, in patients with another severe nerve disease - Machado-Joseph disease (SCA3) - mexiletine treatment led to a decrease in the average number of muscle cramps from 24 to 3 cramps per month.. The safety profile of mexiletine is good, with the most frequent side effects being nausea or other abdominal symptoms. These side effects are rare at the doses (300 mg/day) used in this study. In patients with normal heart function, mexiletine has a minimal effect on heart rhythm. In previous clinical trials, no subject developed any serious heart rate problem. Experimental Plan: Using multiple sites within the State of California we will quickly enroll a small number (N=30) of ALS patients with severe muscle cramps. The study is a double-blinded, placebo controlled (i.e., the investigator and the participant does not know if the pills contain mexiletine or placebo), crossover (all subjects receive two weeks of mexiletine and two weeks of placebo) study. After a one week run in, participants will be evaluated on their ability to fill out the cramp diary. Participants who filled out their diary will be randomly assigned to either mexiletine or placebo for their first two weeks. For the first three days of each 2-week period, one 150mg capsule will be taken at bed time. For day 4 to 14 one capsule twice per day will be taken. Each treatment period will be 2 weeks with an intervening 1 week washout period - for a total study length of 6 weeks. Safety will be monitored with liver function studies and EKG's.
Collaborator(s):
ALS Forum:
First Published on Clinicaltrials.gov: 3/6/2013
ClinicalTrials.gov ID: NCT01811355
Trial Protocol as Published on Clinicaltrials.gov:
ClinicalTrials.gov