Animal Studies

Potential ALS treatments previously studied in the ALS mouse and published by ALS TDI or other researchers are compiled below. Click on a specific study for more detailed information.

	Study	Primary Institute	Model

Treatment:2-PMPA
	Glutamate carboxypeptidase II inhibition protects motor neurons from death in fa...		G93A_Low Copy

Treatment:Adenosine
	Adenosine I	ALSTDF	G93A High Copy
	Adenosine II	ALSTDF	G93A High Copy

Treatment:anisomycin
	Cycloheximide I	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 50	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 65	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 80	ALSTDF	G93A High Copy
	Cycloheximide II High Dose Probe Day 80	ALSTDF	G93A High Copy

Treatment:apocynin
	Apocynin Day 50 Start 150 mg/kg Survival Efficacy Study	ALSTDF	G93A High Copy
	Apocynin Early Start 150 mg/kg Survival Efficacy Study	ALSTDF	G93A High Copy

Treatment:Apomorphine
	Apomorphine I	ALSTDF	G93A High Copy

Treatment:Arimoclomol
	Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease p...		SOD1_G93A1h

Treatment:Aspergillin
	Aspergillin I	ALSTDF	G93A High Copy

Treatment:Bcl-2
	Bcl-2 overexpression does not protect neurons from mutant neurofilament-mediated...		Bcl-2 overexpressor X NF-L (Pro)

Treatment:BMP-7
	Disease course unaltered by a single intracisternal injection of BMP-7 in ALS mi...		"ALS mouse model"

Treatment:Carboxyfullerenes
	Carboxyfullerenes as neuroprotective agents.		SOD1_G93A1h

Treatment:Ceftriaxone
	Ceftriaxone I	ALSTDF	G93A High Copy
	ceftriaxone III	ALSTDF	G93A High Copy
	Ceftriaxone IV	ALSTDF	G93A High Copy
	Pilot Study PBA PK	ALSTDF	G93A High Copy
	Pilot Study Tamoxifen PK I	ALSTDF	G93A High Copy
	Pilot Study Creatine MDA PK	ALSTDF	G93A High Copy
	Tamoxifen MDA PK	ALSTDF	G93A High Copy

Treatment:Celastrol
	Celastrol III LowDose	ALSTDF	G93A High Copy
	LDA Celastrol	ALSTDF	G93A High Copy
	LDA Curcumin I	ALSTDF	G93A High Copy
	LDA Geldanamycin I	ALSTDF	G93A High Copy

Treatment:Celebrex
	Celebrex I	ALSTDF	G93A High Copy
	Celebrex II	ALSTDF	G93A High Copy
	celebrex III	ALSTDF	G93A High Copy
	Pilot Study PBA PK	ALSTDF	G93A High Copy
	Pilot Study Celebrex PK	ALSTDF	G93A High Copy
	Pilot Study Tamoxifen PK I	ALSTDF	G93A High Copy
	Pilot Study Creatine MDA PK	ALSTDF	G93A High Copy
	Tamoxifen MDA PK	ALSTDF	G93A High Copy
	Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a tr...		SOD1_G93A1h

Treatment:CGP 3466B
	CGP 3466B has no effect on disease course of (G93A) mSOD1 transgenic mice.		SOD1_G93A1h

Treatment:Chlorpromazine
	Chlorpromazine I	ALSTDF	G93A High Copy
	Chlorpromazine II	ALSTDF	G93A High Copy

Treatment:Clioquinol
	Clioquinol II	ALSTDF	G93A High Copy
	Clioquinol III	ALSTDF	G93A High Copy
	Clioquinol IV	ALSTDF	G93A High Copy

Treatment:Clozapine
	Opposing effects of low and high-dose clozapine on survival of transgenic amyotr...		SOD1_G93A1h

Treatment:CNTF
	The effects of ciliary neurotrophic factor on neurological function and glial ac...		0

Treatment:Colchicine
	Colchicine I	ALSTDF	G93A High Copy
	Colchicine II	ALSTDF	G93A High Copy

Treatment:colivelin
	Colivelin prolongs survival of an ALS model mouse.		SOD1_G93A1h

Treatment:Copaxone
	Therapeutic vaccine for acute and chronic motor neuron diseases: implications fo...		SOD1_G93A1h
	Copaxone II Repeat	ALSTDF	G93A High Copy

Treatment:Copper Chelators & Lipoic Acid
	Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, tri...		SOD1_G93A1h

Treatment:CoQ10
	Coenzyme Q10 administration increases brain mitochondrial concentrations and exe...		Mutant SOD1 mice
	CoQ10 I	ALSTDF	G93A High Copy

Treatment:Creatine
	Creatine 1	ALSTDF	G93A High Copy
	Pilot Study PBA PK	ALSTDF	G93A High Copy
	Pilot Study Tamoxifen PK I	ALSTDF	G93A High Copy
	Pilot Study Creatine MDA PK	ALSTDF	G93A High Copy
	Tamoxifen MDA PK	ALSTDF	G93A High Copy
	Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral s...		SOD1_G93A1h

Treatment:Creatine & COX-2 inhibitors combined
	Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in ...		SOD1_G93A1h

Treatment:CTLA4-Ig
	Pilot Study Ad-GFP Treatment	ALSTDF	G93A High Copy

Treatment:Curcumin
	LDA Celastrol	ALSTDF	G93A High Copy
	LDA Curcumin I	ALSTDF	G93A High Copy
	LDA Geldanamycin I	ALSTDF	G93A High Copy

Treatment:CVF
	CVF I	ALSTDF	G93A High Copy

Treatment:CYCLOHEXIMIDE
	Cycloheximide I	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 50	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 65	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 80	ALSTDF	G93A High Copy
	Cycloheximide II High Dose Probe Day 80	ALSTDF	G93A High Copy

Treatment:Cycloserine
	Cycloserine I	ALSTDF	G93A High Copy

Treatment:Cyclosporin
	Cyclosporine 1	ALSTDF	G93A High Copy
	Cyclosporin II	ALSTDF	G93A High Copy
	Life span extension and reduced neuronal death after weekly intraventricular cyc...		SOD1_G93A1h
	An ALS mouse model with a permeable blood-brain barrier benefits from systemic c...		G93A SOD1 X mdr1a/b or BBB-KO

Treatment:D-penicillamine
	The copper chelator d-penicillamine delays onset of disease and extends survival...		Mutant SOD1 mice

Treatment:Dapsone � Gusperimus � JAK3 Cocktail
	JAK3/Dapsone I	ALSTDF	G93A High Copy

Treatment:DDC
	DDC I	ALSTDF	G93A High Copy

Treatment:Desferoxamine
	LDA Desferoxamine(DFO)	ALSTDF	G93A High Copy

Treatment:Desipramine
	Desipramine I	ALSTDF	G93A High Copy

Treatment:DFMO
	DFMO I	ALSTDF	G93A High Copy
	DFMO/Ritonavir I Treatment DFMO	ALSTDF	G93A High Copy
	DFMO VI	ALSTDF	G93A High Copy
	DFMO-Ritonavir I Cocktail	ALSTDF	G93A High Copy
	DFMO IV	ALSTDF	G93A High Copy
	DFMO V	ALSTDF	G93A High Copy
	DFMO VII	ALSTDF	G93A High Copy
	DFMO VIII	ALSTDF	G93A High Copy
	DFMO IX	ALSTDF	G93A High Copy
	DFMO X	ALSTDF	G93A High Copy
	LDA DFMO l	ALSTDF	G93A High Copy

Treatment:Dietary Restriction
	No benefit of dietary restriction on disease onset or progression in amyotrophic...		Mutant SOD1 mice

Treatment:dihydrotestosterone
	LDA v1 Norethindrone	ALSTDF	G93A High Copy
	Pilot Study Estradiol Tox	ALSTDF	G93A High Copy
	LDA v1 Dihydrotestosterone I	ALSTDF	G93A High Copy

Treatment:DMPO
	Increased mitochondrial antioxidative activity or decreased oxygen free radical ...		SOD1_G93A1h

Treatment:EAAT2/G93A double transgenic mice
	Increased expression of the glial glutamate transporter EAAT2 modulates excitoto...		EAAT2/G93A double transgenic

Treatment:EGCG
	The effect of epigallocatechin gallate on suppressing disease progression of ALS...		SOD1_G93A1h
	EGCG l	ALSTDF	G93A High Copy

Treatment:EHNA
	LDA EHNA I	ALSTDF	G93A High Copy

Treatment:Emetine
	Cycloheximide I	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 50	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 65	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 80	ALSTDF	G93A High Copy
	Cycloheximide II High Dose Probe Day 80	ALSTDF	G93A High Copy

Treatment:Estradiol Benzoate
	LDA v1 Norethindrone	ALSTDF	G93A High Copy
	Pilot Study Estradiol Tox	ALSTDF	G93A High Copy
	LDA v1 Dihydrotestosterone I	ALSTDF	G93A High Copy

Treatment:Exercise
	Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis...		SOD1_G93A1h

Treatment:FK506
	Immunosuppressant FK506 does not exert beneficial effects in symptomatic G93A su...		Mutant SOD1 mice

Treatment:Fluorouracil
	Fluorouracil II	ALSTDF	G93A High Copy
	Fluorouracil III	ALSTDF	G93A High Copy
	Fluorouracil IV	ALSTDF	G93A High Copy

Treatment:GDNF
	Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor...		Mutant SOD1 mice
	Glial cell line-derived neurotrophic factor protein prevents motor neuron loss o...		Mutant SOD1 mice

Treatment:GDNF (adenovirus-mediated)
	Neuroprotective effects of glial cell line-derived neurotrophic factor mediated ...		SOD1_G93A1h

Treatment:GDNF AAV
	Intramuscular grafts of myoblasts genetically modified to secrete glial cell lin...		SOD1_G93A1h

Treatment:Genetically decreased spinal cord copper concentration
	Genetically decreased spinal cord copper concentration prolongs life in a transg...		G86R

Treatment:Genistein
	Genistein is neuroprotective in murine models of familial amyotrophic lateral sc...		G93A_Low Copy

Treatment:GLUR3 antisense
	Antisense peptide nucleic acid targeting GluR3 delays disease onset and progress...		SOD1_G93A1h

Treatment:Glutamate carboxypeptidase II inhibitor
	Glutamate carboxypeptidase II inhibition protects motor neurons from death in fa...		SOD1_G93A1h

Treatment:HGF
	Overexpression of HGF retards disease progression and prolongs life span in a tr...		Mutant SOD1 mice

Treatment:hNT neuron transplant
	Positive effect of transplantation of hNT neurons (NTera 2/D1 cell-line) in a mo...		SOD1_G93A1h
	hNT neurons delay onset of motor deficits in a model of amyotrophic lateral scle...		"ALS mouse model"

Treatment:hSOD1
	Impaired extracellular secretion of mutant superoxide dismutase 1 associates wit...		SOD1_G93A1h

Treatment:Human umbilical cord blood
	Human umbilical cord blood effect on sod mice (amyotrophic lateral sclerosis).		SOD1_G93A1h
	Intravenous administration of human umbilical cord blood cells in a mouse model ...		SOD1_G93A1h
	The potential for the use of mononuclear cells from human umbilical cord blood i...		SOD1_G93A1h

Treatment:Hydroxyurea
	Hydroxyurea I	ALSTDF	G93A High Copy
	Hydroxyurea II-Females	ALSTDF	G93A High Copy
	Hydroxyurea VI BL6	ALSTDF	G93A High Copy
	Hydroxyurea III	ALSTDF	G93A High Copy
	Hydroxyurea IV	ALSTDF	G93A High Copy
	Hydroxyurea V	ALSTDF	G93A High Copy
	Hydroxyurea VII-males	ALSTDF	G93A High Copy
	Hydroxyurea-EPO I	ALSTDF	G93A High Copy
	LDA Hydroxyurea l	ALSTDF	G93A High Copy
	Hydroxyurea VII-females	ALSTDF	G93A High Copy
	Hydroxyurea II-Males	ALSTDF	G93A High Copy

Treatment:ICE Inhibition
	Inhibition of ICE slows ALS in mice.		mutantSOD(G37R)/mutantICE(M17Z)

Treatment:IGF-1
	Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease.		Wobbler
	Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron d...		Wobbler
	Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in ...		SOD1_G93A1h

Treatment:IGF-1 AAV
	Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.		SOD1_G93A1h

Treatment:IGF-1 isoform
	Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mous...		SOD1_G93A1h

Treatment:IgG
	IgG VI LowDose3	ALSTDF	G93A High Copy

Treatment:Indomethacin
	Indomethacin	ALSTDF	G93A High Copy

Treatment:ipecac
	Cycloheximide I	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 50	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 65	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 80	ALSTDF	G93A High Copy
	Cycloheximide II High Dose Probe Day 80	ALSTDF	G93A High Copy

Treatment:IPI-504
	LDA Celastrol	ALSTDF	G93A High Copy
	LDA Curcumin I	ALSTDF	G93A High Copy
	LDA Geldanamycin I	ALSTDF	G93A High Copy

Treatment:Iron porphyrin
	Iron porphyrin treatment extends survival in a transgenic animal model of amyotr...		SOD1_G93A1h

Treatment:ivermectin
	Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neur...		SOD1_G93A1h

Treatment:L-acetyl-carnitine
	l-Carnitine suppresses the onset of neuromuscular degeneration and increases the...		SOD1_G93A1h

Treatment:Lactacystin
	Pilot Study Lactacystin	ALSTDF	G93A High Copy
	Pilot Study Lactacystin 2	ALSTDF	G93A High Copy
	Pilot Study Lactacystin 2 ug	ALSTDF	G93A High Copy
	Pilot Study Lactacystin 10 ug	ALSTDF	G93A High Copy

Treatment:Leflunomide
	Leflunomide I	ALSTDF	G93A High Copy

Treatment:Lentiviral RNAi SOD1 gene silencing
	Lentiviral-mediated silencing of SOD1 through RNA interference retards disease o...		SOD1_G93A1h

Treatment:LIF � leukemia inhibitory factor
	Behavioural and anatomical effects of systemically administered leukemia inhibit...		SOD1_G93A1h

Treatment:Lithium
	Lithium Survival Efficacy Study (6.94 mg/kg/day lithium ions)	ALSTDF	G93A High Copy

Treatment:Lyophilized red wine extract
	Lyophilized red wine administration prolongs survival in an animal model of amyo...		SOD1_G93A1h

Treatment:Magnesium supplementation
	Magnesium supplementation does not delay disease onset or increase survival in a...		Mutant SOD1 mice

Treatment:Melatonin
	Reduced oxidative damage in ALS by high-dose enteral melatonin treatment.		SOD1_G93A1h

Treatment:Memantine
	Memantine prolongs survival in an amyotrophic lateral sclerosis mouse model.		SOD1_G93A1h

Treatment:Metalloporphyrins � MnTE-Py-P (AEOL10113 and AEOL10150)
	Manganese porphyrin given at symptom onset markedly extends survival of ALS mice...		SOD1_G93A1h

Treatment:Metallothioneins
	Reduction of metallothioneins promotes the disease expression of familial amyotr...		G93A X MT-I and MT-II deficient mice

Treatment:Methotrexate
	Methotrexate I	ALSTDF	G93A High Copy

Treatment:MGF
	Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mous...		SOD1G93A X MLC/mIgf-1 B6J

Treatment:Minocycline
	Minocycline delays disease onset and mortality in a transgenic model of ALS.		SOD1_G93A1h
	Minocycline inhibits cytochrome c release and delays progression of amyotrophic ...		Mutant SOD1 mice
	Cell cycle regulators in the neuronal death pathway of amyotrophic lateral scler...		G37R
	Minocycline slows disease progression in a mouse model of amyotrophic lateral sc...		G37R
	Minocycline I	ALSTDF	G93A High Copy
	Minocycline IV BL6	ALSTDF	G93A High Copy
	Minocycline III	ALSTDF	G93A High Copy
	Minocycline II	ALSTDF	G93A High Copy

Treatment:Minocycline & Creatine in combination
	Additive neuroprotective effects of minocycline with creatine in a mouse model o...		Mutant SOD1 mice

Treatment:Minocycline, riluzole, nimodipine cocktail
	Efficient three-drug cocktail for disease induced by mutant superoxide dismutase...		G37R

Treatment:Mithramycin
	Mithramycin I	ALSTDF	G93A High Copy
	Mithramycin II	ALSTDF	G93A High Copy

Treatment:MPTP and 3-nitropropionic acid
	Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPT...		SOD1_G93A1h

Treatment:N-acetyl-L-cysteine
	The antioxidant N-acetylcysteine does not delay disease onset and death in a tra...		Mutant


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