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Animal Studies



Potential ALS treatments previously studied in the ALS mouse and published by ALS TDI or other researchers are compiled below. Click on a specific study for more detailed information.

Study Primary Institute Model Primary Reference
 
Treatment:2-PMPA  
  G93A_Low Copy  
 
Treatment:Adenosine 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:anisomycin 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:apocynin 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Apomorphine 
  ALSTDF G93A High Copy  
 
Treatment:Arimoclomol 
  SOD1_G93A1h  
 
Treatment:Aspergillin 
  ALSTDF G93A High Copy  
 
Treatment:Bcl-2 
  Bcl-2 overexpressor X NF-L (Pro)  
 
Treatment:BMP-7 
  "ALS mouse model"  
 
Treatment:Carboxyfullerenes 
  SOD1_G93A1h  
 
Treatment:Ceftriaxone 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Celastrol 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Celebrex 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  SOD1_G93A1h  
 
Treatment:CGP 3466B 
  SOD1_G93A1h  
 
Treatment:Chlorpromazine 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Clioquinol  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Clozapine 
  SOD1_G93A1h  
 
Treatment:CNTF 
  0  
 
Treatment:Colchicine 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:colivelin 
  SOD1_G93A1h  
 
Treatment:Copaxone 
  SOD1_G93A1h  
  ALSTDF G93A High Copy  
 
Treatment:Copper Chelators & Lipoic Acid 
  SOD1_G93A1h  
 
Treatment:CoQ10 
  Mutant SOD1 mice  
  ALSTDF G93A High Copy  
 
Treatment:Creatine 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  SOD1_G93A1h  
 
Treatment:Creatine & COX-2 inhibitors combined 
  SOD1_G93A1h  
 
Treatment:CTLA4-Ig 
  ALSTDF G93A High Copy  
 
Treatment:Curcumin 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:CVF 
  ALSTDF G93A High Copy  
 
Treatment:CYCLOHEXIMIDE 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Cycloserine 
  ALSTDF G93A High Copy  
 
Treatment:Cyclosporin 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  SOD1_G93A1h  
  G93A SOD1 X mdr1a/b or BBB-KO  
 
Treatment:D-penicillamine 
  Mutant SOD1 mice  
 
Treatment:Dapsone – Gusperimus – JAK3 Cocktail 
  ALSTDF G93A High Copy  
 
Treatment:DDC 
  ALSTDF G93A High Copy  
 
Treatment:Desferoxamine 
  ALSTDF G93A High Copy  
 
Treatment:Desipramine 
  ALSTDF G93A High Copy  
 
Treatment:DFMO 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Dietary Restriction 
  Mutant SOD1 mice  
 
Treatment:dihydrotestosterone 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:DMPO 
  SOD1_G93A1h  
 
Treatment:EAAT2/G93A double transgenic mice 
  EAAT2/G93A double transgenic  
 
Treatment:EGCG 
  SOD1_G93A1h  
  ALSTDF G93A High Copy  
 
Treatment:EHNA 
  ALSTDF G93A High Copy  
 
Treatment:Emetine 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Estradiol Benzoate 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Exercise 
  SOD1_G93A1h  
 
Treatment:FK506 
  Mutant SOD1 mice  
 
Treatment:Fluorouracil 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:GDNF 
  Mutant SOD1 mice  
  Mutant SOD1 mice  
 
Treatment:GDNF (adenovirus-mediated) 
  SOD1_G93A1h  
 
Treatment:GDNF AAV 
  SOD1_G93A1h  
 
Treatment:Genetically decreased spinal cord copper concentration 
  G86R  
 
Treatment:Genistein 
  G93A_Low Copy  
 
Treatment:GLUR3 antisense 
  SOD1_G93A1h  
 
Treatment:Glutamate carboxypeptidase II inhibitor 
  SOD1_G93A1h  
 
Treatment:HGF 
  Mutant SOD1 mice  
 
Treatment:hNT neuron transplant 
  SOD1_G93A1h  
  "ALS mouse model"  
 
Treatment:hSOD1 
  SOD1_G93A1h  
 
Treatment:Human umbilical cord blood 
  SOD1_G93A1h  
  SOD1_G93A1h  
  SOD1_G93A1h  
 
Treatment:Hydroxyurea 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:ICE Inhibition 
  mutantSOD(G37R)/mutantICE(M17Z)  
 
Treatment:IGF-1 
  Wobbler  
  Wobbler  
  SOD1_G93A1h  
 
Treatment:IGF-1 AAV  
  SOD1_G93A1h  
 
Treatment:IGF-1 isoform 
  SOD1_G93A1h  
 
Treatment:IgG 
  ALSTDF G93A High Copy  
 
Treatment:Indomethacin 
  ALSTDF G93A High Copy  
 
Treatment:ipecac 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:IPI-504 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Iron porphyrin 
  SOD1_G93A1h  
 
Treatment:ivermectin 
  SOD1_G93A1h  
 
Treatment:L-acetyl-carnitine 
  SOD1_G93A1h  
 
Treatment:Lactacystin 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Leflunomide 
  ALSTDF G93A High Copy  
 
Treatment:Lentiviral RNAi SOD1 gene silencing 
  SOD1_G93A1h  
 
Treatment:LIF – leukemia inhibitory factor 
  SOD1_G93A1h  
 
Treatment:Lithium 
  ALSTDF G93A High Copy  
 
Treatment:Lyophilized red wine extract 
  SOD1_G93A1h  
 
Treatment:Magnesium supplementation  
  Mutant SOD1 mice  
 
Treatment:Melatonin 
  SOD1_G93A1h  
 
Treatment:Memantine 
  SOD1_G93A1h  
 
Treatment:Metalloporphyrins – MnTE-Py-P (AEOL10113 and AEOL10150) 
  SOD1_G93A1h  
 
Treatment:Metallothioneins 
  G93A X MT-I and MT-II deficient mice  
 
Treatment:Methotrexate 
  ALSTDF G93A High Copy  
 
Treatment:MGF 
  SOD1G93A X MLC/mIgf-1 B6J  
 
Treatment:Minocycline 
  G37R  
  G37R  
  SOD1_G93A1h  
  Mutant SOD1 mice  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Minocycline & Creatine in combination 
  Mutant SOD1 mice  
 
Treatment:Minocycline, riluzole, nimodipine cocktail 
  G37R  
 
Treatment:Mithramycin 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:MPTP and 3-nitropropionic acid 
  SOD1_G93A1h  
 
Treatment:N-acetyl-L-cysteine  
  SOD1_G93A1h  
  Wobbler  
  Mutant SOD1 mice  
 
Treatment:N-acetylcysteine 
  Mutant SOD1 mice  
 
Treatment:NBQX 
  SOD1_G93A1h  
 
Treatment:NDGA 
  SOD1_G93A1h  
  ALSTDF G93A High Copy  
 
Treatment:neurofilament light chain promoter G37R FALS mouse 
  G37R neurofilament light chain promoter  
 
Treatment:NF-H or NF-L Overexpression 
  mice expressing, solely or concomitantly, the hNF-H and (hNF-L) proteins  
 
Treatment:Nimesulide 
  SOD1_G93A1h  
 
Treatment:NOS Inhibitors 
  Mutant SOD1 mice  
 
Treatment:Ovariectomy w/17beta-estradiol  
  SOD1_G93A1h  
 
Treatment:p75 neurotrophin receptor KO X G93A SOD1  
  p75NTR-KOxG93A SOD1  
 
Treatment:p75NTR Antagonist 
  SOD1_G93A1h  
 
Treatment:p75NTR Antisense 
  SOD1_G93A1h  
 
Treatment:parvalbumin  
  Parvalbumin overexpressor X G93A SOD1  
 
Treatment:PBA 
  SOD1_G93A1h  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Peripheral Axotomy 
  SOD1_G93A1h  
 
Treatment:Peripherin overexpressor & -/- model 
  G37R;TgPer mice & G37R;Per-/- mice  
 
Treatment:Phosphatidyl choline-bound Cu/Zn SOD  
  Wobbler  
 
Treatment:Pioglitazone 
  SOD1_G93A1h  
  SOD1_G93A1h  
 
Treatment:polyamine-modified catalase  
  "ALS mouse model"  
 
Treatment:Porphyrin  
  ALSTDF G93A High Copy  
 
Treatment:Prednisolone 
  ALSTDF G93A High Copy  
 
Treatment:Progesterone 
  Wobbler  
 
Treatment:Puromycin 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:PUT-CAT 
  SOD1_G93A1h  
 
Treatment:Quinacrine 
  ALSTDF G93A High Copy  
 
Treatment:R(+) Pramipexole 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  SOD1_G93A1h  
 
Treatment:rabies G (RabG) protein pseudotyped lentiviral vector EIAV.LacZ  
  SOD1_G93A1h  
 
Treatment:Radicicol 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Rasagiline 
  SOD1_G93A1h  
 
Treatment:Resveratrol / red wine extract 
  SOD1_G93A1h  
 
Treatment:Riluzole 
  Wobbler  
  Rat model:Tac:N:(SD)-TgN(SOD1G93A)L26H  
  "ALS mouse model"  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Ritonavir 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:RK35 
  SOD1_G93A1h  
 
Treatment:rmVEGF  
  SOD1_G93A1h  
 
Treatment:RNAi targeting human SOD1 gene 
  SOD1_G93A1h  
 
Treatment:Rofecoxib 
  SOD1_G93A1h  
 
Treatment:Rolipram 
  ALSTDF G93A High Copy  
 
Treatment:RPR 119990 
  SOD1_G93A1h  
 
Treatment:serotonin precursor 5-HTP 
  SOD1_G93A1h  
 
Treatment:SOD1 G37R;Triple Heterozygous knockout mice 
  SOD1 G37R +/-;NF-L null X double NF-M/H KO  
 
Treatment:SOD1(G37R);NF-H transgenic mice 
  SOD1(G37R);NF-H  
 
Treatment:Sodium Valproate 
  ALSTDF G93A High Copy  
 
Treatment:Stem cells in ALS Rat 
  Rat model:Tac:N:(SD)-TgN(SOD1G93A)L26H  
 
Treatment:Sulindac 
  SOD1_G93A1h  
 
Treatment:Tamoxifen 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:TCH-346 
  SOD1_G93A1h  
 
Treatment:Tepoxalin 
  ALSTDF G93A High Copy  
 
Treatment:testosterone 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Thalidomide 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Trehalose 
  ALSTDF G93A High Copy  
 
Treatment:Trichostatin A 
  ALSTDF G93A High Copy  
 
Treatment:trientine/ascorbate 
  SOD1_G93A1h  
 
Treatment:VEGF 
  VEGFa (delta/delta) X G93A SOD1  
  SOD1_G93A1h  
 
Treatment:Vincristine 
  SOD1_G93A1h  
 
Treatment:Vitamin E, riluzole, and gabapentin  
  Mutant SOD1 mice  
 
Treatment:WHI-P131 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:WT bone marrow stem cell Transplant in SOD1 mice 
  SOD1_G93A1h  
 
Treatment:Zileuton 
  ALSTDF G93A High Copy  
  ALSTDF G93A High Copy  
 
Treatment:Zinc Sulfate 
  SOD1_G93A1h  
  SOD1_G93A1h  
 
Treatment:ZK 187638 
  SOD1_G93A1h  
 
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