Animal Studies

Four to six drug-screening studies are initiated each month in the SOD1 G93A mouse (the genetic mouse model of ALS); each study includes 40 to 50 mice. We house approximately 1,000 mice in our facility and more than 12 drug studies are ongoing at any one time.

	Study	Primary Institute	Model

Treatment:Adenosine
	Adenosine I	ALSTDF	G93A High Copy
	Adenosine II	ALSTDF	G93A High Copy

Treatment:anisomycin
	Cycloheximide I	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 50	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 65	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 80	ALSTDF	G93A High Copy
	Cycloheximide II High Dose Probe Day 80	ALSTDF	G93A High Copy

Treatment:apocynin
	Apocynin Day 50 Start 150 mg/kg Survival Efficacy Study	ALSTDF	G93A High Copy
	Apocynin Early Start 150 mg/kg Survival Efficacy Study	ALSTDF	G93A High Copy
	Apocynin Early Start 150 mg/kg Survival Efficacy Repeat	ALSTDF	G93A High Copy

Treatment:Apomorphine
	Apomorphine I	ALSTDF	G93A High Copy

Treatment:Aspergillin
	Aspergillin I	ALSTDF	G93A High Copy

Treatment:Ceftriaxone
	Ceftriaxone I	ALSTDF	G93A High Copy
	ceftriaxone III	ALSTDF	G93A High Copy
	Ceftriaxone IV	ALSTDF	G93A High Copy
	Pilot Study PBA PK	ALSTDF	G93A High Copy
	Pilot Study Tamoxifen PK I	ALSTDF	G93A High Copy
	Pilot Study Creatine MDA PK	ALSTDF	G93A High Copy
	Tamoxifen MDA PK	ALSTDF	G93A High Copy

Treatment:Celastrol
	Celastrol III LowDose	ALSTDF	G93A High Copy
	LDA Celastrol	ALSTDF	G93A High Copy
	LDA Curcumin I	ALSTDF	G93A High Copy
	LDA Geldanamycin I	ALSTDF	G93A High Copy

Treatment:Celebrex
	Celebrex I	ALSTDF	G93A High Copy
	Celebrex II	ALSTDF	G93A High Copy
	celebrex III	ALSTDF	G93A High Copy
	Pilot Study PBA PK	ALSTDF	G93A High Copy
	Pilot Study Celebrex PK	ALSTDF	G93A High Copy
	Pilot Study Tamoxifen PK I	ALSTDF	G93A High Copy
	Pilot Study Creatine MDA PK	ALSTDF	G93A High Copy
	Tamoxifen MDA PK	ALSTDF	G93A High Copy

Treatment:Chlorpromazine
	Chlorpromazine I	ALSTDF	G93A High Copy
	Chlorpromazine II	ALSTDF	G93A High Copy

Treatment:Clioquinol
	Clioquinol II	ALSTDF	G93A High Copy
	Clioquinol III	ALSTDF	G93A High Copy
	Clioquinol IV	ALSTDF	G93A High Copy

Treatment:Colchicine
	Colchicine I	ALSTDF	G93A High Copy
	Colchicine II	ALSTDF	G93A High Copy

Treatment:Copaxone
	Copaxone II Repeat	ALSTDF	G93A High Copy

Treatment:CoQ10
	CoQ10 I	ALSTDF	G93A High Copy

Treatment:Creatine
	Creatine 1	ALSTDF	G93A High Copy
	Pilot Study PBA PK	ALSTDF	G93A High Copy
	Pilot Study Tamoxifen PK I	ALSTDF	G93A High Copy
	Pilot Study Creatine MDA PK	ALSTDF	G93A High Copy
	Tamoxifen MDA PK	ALSTDF	G93A High Copy

Treatment:CTLA4-Ig
	Pilot Study Ad-GFP Treatment	ALSTDF	G93A High Copy

Treatment:Curcumin
	LDA Celastrol	ALSTDF	G93A High Copy
	LDA Curcumin I	ALSTDF	G93A High Copy
	LDA Geldanamycin I	ALSTDF	G93A High Copy

Treatment:CVF
	CVF I	ALSTDF	G93A High Copy

Treatment:CYCLOHEXIMIDE
	Cycloheximide I	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 50	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 65	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 80	ALSTDF	G93A High Copy
	Cycloheximide II High Dose Probe Day 80	ALSTDF	G93A High Copy

Treatment:Cycloserine
	Cycloserine I	ALSTDF	G93A High Copy

Treatment:Cyclosporin
	Cyclosporine 1	ALSTDF	G93A High Copy
	Cyclosporin II	ALSTDF	G93A High Copy

Treatment:Dapsone � Gusperimus � JAK3 Cocktail
	JAK3/Dapsone I	ALSTDF	G93A High Copy

Treatment:DDC
	DDC I	ALSTDF	G93A High Copy

Treatment:Desferoxamine
	LDA Desferoxamine(DFO)	ALSTDF	G93A High Copy

Treatment:Desipramine
	Desipramine I	ALSTDF	G93A High Copy

Treatment:DFMO
	DFMO I	ALSTDF	G93A High Copy
	DFMO/Ritonavir I Treatment DFMO	ALSTDF	G93A High Copy
	DFMO VI	ALSTDF	G93A High Copy
	DFMO-Ritonavir I Cocktail	ALSTDF	G93A High Copy
	DFMO IV	ALSTDF	G93A High Copy
	DFMO V	ALSTDF	G93A High Copy
	DFMO VII	ALSTDF	G93A High Copy
	DFMO VIII	ALSTDF	G93A High Copy
	DFMO IX	ALSTDF	G93A High Copy
	DFMO X	ALSTDF	G93A High Copy
	LDA DFMO l	ALSTDF	G93A High Copy

Treatment:dihydrotestosterone
	LDA v1 Norethindrone	ALSTDF	G93A High Copy
	Pilot Study Estradiol Tox	ALSTDF	G93A High Copy
	LDA v1 Dihydrotestosterone I	ALSTDF	G93A High Copy

Treatment:EGCG
	EGCG l	ALSTDF	G93A High Copy

Treatment:EHNA
	LDA EHNA I	ALSTDF	G93A High Copy

Treatment:Emetine
	Cycloheximide I	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 50	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 65	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 80	ALSTDF	G93A High Copy
	Cycloheximide II High Dose Probe Day 80	ALSTDF	G93A High Copy

Treatment:Estradiol Benzoate
	LDA v1 Norethindrone	ALSTDF	G93A High Copy
	Pilot Study Estradiol Tox	ALSTDF	G93A High Copy
	LDA v1 Dihydrotestosterone I	ALSTDF	G93A High Copy

Treatment:Fluorouracil
	Fluorouracil II	ALSTDF	G93A High Copy
	Fluorouracil III	ALSTDF	G93A High Copy
	Fluorouracil IV	ALSTDF	G93A High Copy

Treatment:Hydroxyurea
	Hydroxyurea I	ALSTDF	G93A High Copy
	Hydroxyurea II-Females	ALSTDF	G93A High Copy
	Hydroxyurea VI BL6	ALSTDF	G93A High Copy
	Hydroxyurea III	ALSTDF	G93A High Copy
	Hydroxyurea IV	ALSTDF	G93A High Copy
	Hydroxyurea V	ALSTDF	G93A High Copy
	Hydroxyurea VII-males	ALSTDF	G93A High Copy
	Hydroxyurea-EPO I	ALSTDF	G93A High Copy
	LDA Hydroxyurea l	ALSTDF	G93A High Copy
	Hydroxyurea VII-females	ALSTDF	G93A High Copy
	Hydroxyurea II-Males	ALSTDF	G93A High Copy

Treatment:IgG
	IgG VI LowDose3	ALSTDF	G93A High Copy

Treatment:Indomethacin
	Indomethacin	ALSTDF	G93A High Copy

Treatment:ipecac
	Cycloheximide I	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 50	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 65	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 80	ALSTDF	G93A High Copy
	Cycloheximide II High Dose Probe Day 80	ALSTDF	G93A High Copy

Treatment:IPI-504
	LDA Celastrol	ALSTDF	G93A High Copy
	LDA Curcumin I	ALSTDF	G93A High Copy
	LDA Geldanamycin I	ALSTDF	G93A High Copy

Treatment:Lactacystin
	Pilot Study Lactacystin	ALSTDF	G93A High Copy
	Pilot Study Lactacystin 2	ALSTDF	G93A High Copy
	Pilot Study Lactacystin 2 ug	ALSTDF	G93A High Copy
	Pilot Study Lactacystin 10 ug	ALSTDF	G93A High Copy

Treatment:Leflunomide
	Leflunomide I	ALSTDF	G93A High Copy

Treatment:Lithium
	Lithium Survival Efficacy Study (6.94 mg/kg/day lithium ions)	ALSTDF	G93A High Copy

Treatment:Methotrexate
	Methotrexate I	ALSTDF	G93A High Copy

Treatment:Minocycline
	Minocycline I	ALSTDF	G93A High Copy
	Minocycline IV BL6	ALSTDF	G93A High Copy
	Minocycline III	ALSTDF	G93A High Copy
	Minocycline II	ALSTDF	G93A High Copy

Treatment:Mithramycin
	Mithramycin I	ALSTDF	G93A High Copy
	Mithramycin II	ALSTDF	G93A High Copy

Treatment:NDGA
	NDGA I	ALSTDF	G93A High Copy

Treatment:PBA
	Sodium Phenyl Butyrate I	ALSTDF	G93A High Copy
	sodium phenyl butyrate (PBA) II	ALSTDF	G93A High Copy
	Sodium phenyl butyrate IV PBA200	ALSTDF	G93A High Copy
	Pilot Study PBA PK	ALSTDF	G93A High Copy
	LDA PBA	ALSTDF	G93A High Copy
	Pilot Study Tamoxifen PK I	ALSTDF	G93A High Copy
	Pilot Study Creatine MDA PK	ALSTDF	G93A High Copy
	Tamoxifen MDA PK	ALSTDF	G93A High Copy

Treatment:Porphyrin
	Porphyrin I	ALSTDF	G93A High Copy

Treatment:Prednisolone
	Prednisolone I	ALSTDF	G93A High Copy

Treatment:Puromycin
	Cycloheximide I	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 50	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 65	ALSTDF	G93A High Copy
	Cycloheximide I High Dose Probe Day 80	ALSTDF	G93A High Copy
	Cycloheximide II High Dose Probe Day 80	ALSTDF	G93A High Copy

Treatment:Quinacrine
	Quinacrine I	ALSTDF	G93A High Copy

Treatment:R(+) Pramipexole
	R(+) Pramipexole 100	ALSTDF	G93A High Copy
	R(+) Pramipexole 300	ALSTDF	G93A High Copy

Treatment:Radicicol
	LDA Celastrol	ALSTDF	G93A High Copy
	LDA Curcumin I	ALSTDF	G93A High Copy
	LDA Geldanamycin I	ALSTDF	G93A High Copy

Treatment:Riluzole
	Riluzole I	ALSTDF	G93A High Copy
	Riluzole II	ALSTDF	G93A High Copy
	Riluzole lll	ALSTDF	G93A High Copy
	Riluzole lll Tissue	ALSTDF	G93A High Copy
	Riluzole lV	ALSTDF	G93A High Copy
	Riluzole V	ALSTDF	G93A High Copy
	LDA Riluzole l	ALSTDF	G93A High Copy

Treatment:Ritonavir
	DFMO I	ALSTDF	G93A High Copy
	DFMO/Ritonavir I Treatment DFMO	ALSTDF	G93A High Copy
	DFMO VI	ALSTDF	G93A High Copy
	DFMO-Ritonavir I Cocktail	ALSTDF	G93A High Copy
	DFMO IV	ALSTDF	G93A High Copy
	DFMO V	ALSTDF	G93A High Copy
	DFMO VII	ALSTDF	G93A High Copy
	DFMO VIII	ALSTDF	G93A High Copy
	DFMO IX	ALSTDF	G93A High Copy
	DFMO X	ALSTDF	G93A High Copy
	LDA DFMO l	ALSTDF	G93A High Copy
	Ritonavir I	ALSTDF	G93A High Copy
	Ritonavir II	ALSTDF	G93A High Copy
	Ritonavir IV	ALSTDF	G93A High Copy
	Ritonavir VIII	ALSTDF	G93A High Copy
	Ritonavir IX	ALSTDF	G93A High Copy

Treatment:Rolipram
	Rolipram I	ALSTDF	G93A High Copy

Treatment:Sodium Valproate
	Sodium Valproate I	ALSTDF	G93A High Copy

Treatment:Tamoxifen
	Pilot Study PBA PK	ALSTDF	G93A High Copy
	Tamoxifen I	ALSTDF	G93A High Copy
	Pilot Study Tamoxifen PK I	ALSTDF	G93A High Copy
	Pilot Study Creatine MDA PK	ALSTDF	G93A High Copy
	Tamoxifen MDA PK	ALSTDF	G93A High Copy

Treatment:Tepoxalin
	Tepoxalin I	ALSTDF	G93A High Copy

Treatment:testosterone
	LDA v1 Norethindrone	ALSTDF	G93A High Copy
	Pilot Study Estradiol Tox	ALSTDF	G93A High Copy
	LDA v1 Dihydrotestosterone I	ALSTDF	G93A High Copy

Treatment:Thalidomide
	Thalidomide I (7.69mg/kg/d IP)	ALSTDF	G93A High Copy
	Thalidomide II (100mg/kg)	ALSTDF	G93A High Copy
	Thalidomide III (200mg/kg)	ALSTDF	G93A High Copy
	Thalidomide III.5 (TDF-366)	ALSTDF	G93A High Copy
	Thalidomide IV A & B	ALSTDF	G93A High Copy

Treatment:Trehalose
	Trehalose I	ALSTDF	G93A High Copy

Treatment:Trichostatin A
	Trichostatin A I	ALSTDF	G93A High Copy

Treatment:WHI-P131
	JAK3 I Day 60	ALSTDF	G93A High Copy
	JAK3 II Day 90	ALSTDF	G93A High Copy
	JAK3 III	ALSTDF	G93A High Copy

Treatment:Zileuton
	Zileuton I	ALSTDF	G93A High Copy
	Zileuton II	ALSTDF	G93A High Copy