Dexpramipexole

Highly related to the Parkinson’s disease drug pramipexole (Mirapex), the neuroprotectant dexpramipexole (Empower) may slow the progression of ALS by keeping the power on in deteriorating motor nerves. Dexpramipexole is thought to maintain mitochondrial function in people with ALS by increasing the efficiency of ATP production.

Status

Type: Small Molecule
Stage: Completed
Status: Completed
Sponsor: Biogen Idec

TDI Says:

A Phase III clinical trial on dexpramipexole was completed in 2012. Results and analysis reported by clinical trial sponsor Biogen Idec showed no statistically significant slowing of disease progression in people with ALS treated with dexpramipexole compared to those treated with placebo.

Learn More

  • ALS clinical trials, powering forward

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  • ALS, off the beaten track

    Emerging ALS mitochondrial-targeted medicines are gathering steam. But, these medicines may need to do a lot more than boost energy production to stop the disease.

Published Results

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