Answer ALS: Individualized Initiative for ALS Discovery

Answer ALS: Individualized Initiative for ALS Discovery

Quick Info:

Status:
Currently Recruiting
Estimated Enrollment:
1000
Phase:
Treatment Type:
Trial Type:
Observational
Sponsor:
Johns Hopkins University
Primary Investigator:
Contact Information:

Trial Goal:

Biobanks

Biobanks

PALS tissues help scientists identify potential biomarkers and drugs
Tests to Expect:
Blood Draw

Blood Draw

Questionnaire

Questionnaire

Cognitive Tests

Cognitive Tests

Update Notes:

4/11/2018Location updated
2/13/2018No significant updates
1/29/2018Locations updated
4/24/2017Eligibility and Description updated
8/23/2016Recruitment status updated
5/27/2016No Significant Changes
2/1/2016Locations updated.
1/14/2016Recruitment status updated.
10/20/2015Clinical trial added.

Locations:

Emory University, Atlanta, 30322
Johns Hopkins University, Baltimore, 21205
Massachusetts General Hospital, Boston, 02114
Washington University School of Medicine, St. Louis, 63110
Ohio State University Wexner Medical Center, Columbus, 43221
Cedars-Sinai Medical Center, Los Angeles, 90048
Texas Neurology, Dallas, 75214
Northwestern University Feinberg School of Medicin, Chicago, 60611

Other Information:

Purpose: Creation of a large repository of induced pluripotent stem cells (iPSC), bio-fluid samples (blood and spinal fluid (optional)), and cell lines for ALS gene identification. This will be combined carefully with collected measures of the pattern of the symptoms people with ALS have and how these change over time. People with other motor neuron diseases and healthy controls will be included as comparisons
Eligibility: 18 Years to 100 Years, all Genders, accepting Healthy Volunteers, Non-Probability Sample
Details: Patients will have 5 study visits; screening, 3, 6, 9 and 12 months. There will be a one year post-participation follow-up period, during which they will receive an email or phone call interview once every 3 months. During the first year, samples will be collected, breathing, muscle strength, spasticity, general function and cognitive behavior will be assessed. Healthy controls will have 2 study visits during which blood samples will be collected and questionnaires given.
Collaborator(s):
News Articles and Summaries:
ALS Forum:
First Published on Clinicaltrials.gov: 10/9/2015
ClinicalTrials.gov ID: NCT02574390
Trial Protocol as Published on Clinicaltrials.gov:
ClinicalTrials.gov