Quick Info
Status
Ongoing, But Not Recruiting
Estimated Enrollment
1000
Phase
-
Treatment Type
Trial Type
Observational
Primary Investigator
Betsy Mosmiller, BA
Contact Information
Locations
Emory University, Atlanta, 30322
Johns Hopkins University, Baltimore, 21205
Massachusetts General Hospital, Boston, 02114
Washington University School of Medicine, St. Louis, 63110
Ohio State University Wexner Medical Center, Columbus, 43221
Cedars-Sinai Medical Center, Los Angeles, 90048
Texas Neurology, Dallas, 75214
Northwestern University Feinberg School of Medicin, Chicago, 60611
Trial Goal
Biobanks
PALS tissues help scientists identify potential biomarkers and drugs
Tests to Expect
Blood Draw
Questionnaire
Cognitive Tests
Update Notes
No significant updates
2/11/2019
Recruitment status updated
1/11/2019
No significant updates
5/5/2018
Location updated
4/11/2018
No significant updates
2/13/2018
Locations updated
1/29/2018
Eligibility and Description updated
4/24/2017
Recruitment status updated
8/23/2016
No Significant Changes
5/27/2016
Locations updated.
2/1/2016
Recruitment status updated.
1/14/2016
Clinical trial added.
10/20/2015

Other Information

Purpose
Creation of a large repository of induced pluripotent stem cells (iPSC), bio-fluid samples (blood and spinal fluid (optional)), and cell lines for ALS gene identification. This will be combined carefully with collected measures of the pattern of the symptoms people with ALS have and how these change over time. People with other motor neuron diseases and healthy controls will be included as comparisons
Eligibility
18 Years to 100 Years, all Genders, accepting Healthy Volunteers, Non-Probability Sample
Details
Patients will have 5 study visits; screening, 3, 6, 9 and 12 months. There will be a one year post-participation follow-up period, during which they will receive an email or phone call interview once every 3 months. During the first year, samples will be collected, breathing, muscle strength, spasticity, general function and cognitive behavior will be assessed. Healthy controls will have 2 study visits during which blood samples will be collected and questionnaires given.
News Articles and Summaries
    -
ALS Forum
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Trial Protocol as Published on Clinicaltrials.gov
NCT02574390 (First Published: 10/9/2015)