Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS

Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS

Quick Info:

Status:
Currently Recruiting
Estimated Enrollment:
24
Phase:
Treatment Type:
Expiratory Muscle Strength Training (EMST) and Lung Volume Recruitment (LVR)
Trial Type:
Randomized, Parallel Assignment
Sponsor:
University of Minnesota - Clinical and Translational Science Institute
Primary Investigator:
Contact Information:

Enrollment Criteria:

Forced Ventilation

Breathing Ability

Percent lung function (FVC) or (SVC)
> 65%
Months/Onset

Months Since Onset

Number of months since first
symptoms of ALS
not specified
BiPap Allowed

Non-Invasive Ventilation (NIV)

Can PALS use a BiPAP in the trial?
not specified
DPS Allowed

Diaphragm Pacer (DPS)

Can PALS use a DPS in the trial?
not specified
Edaravone Usage

Edaravone Usage

Can a PALS use edaravone (Radicut/Radicava)
while enrolled in the trial?
Unknown

Update Notes:

2/15/2018Recruitment status updated
11/9/2017No significant updates
9/8/2017No significant updates
7/10/2017Trial added

Locations:

University of Minnesota, Minneapolis, 55455
University of Florida, Gainsville, 32611

Other Information:

Purpose: The purpose of this study is to investigate the effects of two treatment techniques called Expiratory Muscle Strength Training (EMST) and Lung Volume Recruitment (LVR) on breathing, swallowing, speech, and cough function in persons with mild to moderate ALS. Half of the participants will do EMST alone, and the other half of the participants will do EMST and LVR.
Eligibility: 18 years or older, all genders, not accepting healthy volunteers
Details:
Collaborator(s):
News Articles and Summaries:
ALS Forum:
First Published on Clinicaltrials.gov: 6/26/2017
ClinicalTrials.gov ID: NCT03202017
Trial Protocol as Published on Clinicaltrials.gov:
ClinicalTrials.gov