Inclusion Criteria:
- Diagnosis of Amyotrophic Lateral Sclerosis.
- Understanding and willingness to sign a written informed consent document Exclusion Criteria:
- Active infection - Active cancer - Chronic multisystem organ failure - Pregnancy - Anticoagulation medicine use - Clinically significant Abnormalities on pre-treatment laboratory evaluation - Medical condition that would (based on the opinion of the investigator) compromise patient's safety.
- Previous organ transplant - Hypersensitivity to sulfur - Continued drug abuse - Pre-menopausal women not using contraception

Amyotrophic lateral sclerosis is a devastating disease. There is evidence that mesenchymal stem cell treatment is safe and can improve the prognosis of afflicted patients. Patients with ALS will receive three intrathecal injections of cultured allogeneic adult umbilical cord derived mesenchymal stem cells. The dose for each injection will be 50 million cells and the injections will be at two-month intervals. Patients will be evaluated within one month pre treatment and at 1, 6, 12, 24, 36, and 48 months post treatment for safety and efficacy.

• The Foundation for Orthopaedics and Regenerative Medicine

NCT05003921 (First Published: 8/6/2021)