I've posted it before but here it is again:

L-Lysine..................2000 mg
L-Arginine................2000 mg
Acetyl-L-Carnitine ...2000 mg
L-Taurine.................2000 mg
L-Glutamine.............2000 mg
Niacin.......................2000 mg
Choline.....................2000 mg

Most of the above supplements are known to promote vasodilation and angiogenesis. In addition, my wife takes 1 mg of Estradiol and progesterone every day. I found out that estrogen is a powerful vasodilator and promotes angiogenesis. Hopefully, someone might suggest a male equivalent that does the same thing.

With the exception of taurine and carnitine, I recommend that PALS stay away from all anti-oxidants. You want more oxygen in the blood, not less. Stay oxygenated by all means possible. If you can get hyperbaric oxygen therapy several times a week, get it. Also, if at all possible, stay away from pain killers, anti-anxiety medicines, opiate derivatives, vaccines and all vasoconstrictors such as antihistamines and cocaine-based products.

PS. I should add that I owe most of my insights into this disease to Nemesis. Thank you Nemesis. My wife and I owe you a huge debt of gratitude. I believe that she will beat this disease. And when she does, I will send you a case of fine French Champagne.

Thanks. I'll read up on them and find out if they have any adverse effects on males.
Actually, my wife does take 1000 mg of magnesium every day. I did not include it in the list because it also causes diarrhea at higher doses. Diarrhea can be a major pain if you're paralyzed or partially paralyzed and some people are more sensitive than others.

But magnesium also has angiogenic properties in addition to being a vasodilator. So consider it part of the regimen from now on.

Louis

Can't say that I do, though in general I'm not much help when it comes to the biological side of things anyway. However, from what others have posted it seems that even the researchers in the actual trials are only monitoring various peripheral aspects of subjects' blood, so my guess is that there probably just isn't a good way to do it.

The best we might be able to do is try to quantify the overall presence of chlorite in the blood over time. Such a concept is based on these results:

https://docs.google.com/file/d/0B5nmEImgaRfuMmExOWJhOTItNTk2My00Y2M5LTk2NTItNzgyYmFlYzg5Zjcz/edit

which establish that the only oxidizing moieties in the bloodstream following ingestion of chlorite are the chlorite molecules themselves (along with hypochlorite generated directly from the metabolism of the chlorite). As such, by monitoring the levels of certain antioxidants in the bloodstream and comparing them to an initial baseline reading, we might be able to at least estimate the oxidative load of the chlorite being delivered to a given patient's bloodstream.


Before we get too far down this path, I should qualify that the calculations I did last week to estimate the half-life of chlorite in the bloodstream are at best a gross oversimplification, and at worst flat out meaningless. Besides the fact that the data I used were taken from second-hand accounts of research that was done on rats rather than humans, I also assumed that the absorption and elimination of chlorite followed an exponential decay pattern, which is specifically rejected in the abstract of one of the journal articles: "36Cl excretion was greatest at 24 hours after the administration of 36ClO3-, but in the 36ClO2-, the excretion most likely represented saturation of the biotransformation and excretion pathways."

The truth is that the literature information available to us is nowhere near robust enough to allow us to make definitive statements about the activity of chlorite. However, we can still use that information to determine the realm of possibilities for how chlorite behaves at various stages between ingestion and excretion. By giving ourselves some idea of what we know (and what we don't know), we can better identify possible reasons for the issues that arise (such as fatigue, lack of benefit, or loss of efficacy) and also formulate potential solutions.

I'm actually preparing another post that addresses this approach in much more depth. I should have it ready in a day or two.

Mike

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"If I have seen a little further it is by standing on the shoulders of Giants." - Isaac Newton

Hey Chemister, sometimes its easier just to say; I agree, rather than saying the same thing in another way.

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Don't just ask what scientists can do to speed up the solution for ALS or when they will do it, instead ask yourself what you can do right now to solve ALS asap.

No problems, I kind of expected that you might have missed the post since it was masked by irrelevant postings.

Yes, believe that it is fair to say that I have considerable expertise in multivariate modeling and multivariate calibration.

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Don't just ask what scientists can do to speed up the solution for ALS or when they will do it, instead ask yourself what you can do right now to solve ALS asap.

Well in that case, the first question I'd have about such models would concern their practicality for our purposes: for the moment, let's suppose that you were actually able to successfully develop a protocol for testing one's antioxidant levels, comparing them to baseline results, and subsequently estimating the total amount of chlorite absorbed into the bloodstream.

In all likelihood, what basic requirements would we be talking about then for the individuals who wanted to utilize this protocol? To what extent would these individuals have to get actual lab testing done on their blood samples (and how affordable would such testing be)? How much might the protocol have to be calibrated to each individual in order to yield useful information? How much could we expect the average PALS to have to rely on help from others (either on this site or elsewhere) to interpret their results, perform calculations, etc.?

Obviously you can't provide specific answers to these questions right now, but based on your experience, what might some reasonable expectations be?

Mike

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"If I have seen a little further it is by standing on the shoulders of Giants." - Isaac Newton

This is a substantial project and that is why it will probably never will be completed. Even if it did, a pilot-study in mice would probably be required.

This is a quick & rough outline:

There are two phases to this project; the first is to establish the model. For this phase we would need a number of volunteers I would aim for more than 20, preferably 40-50, where some, say ½ of them are healthy.

We also need to figure what indirect indices of oxidation to use (as many as possible in the initial phase).

Then all subjects will be asked to abstain from antioxidants and to take a one week wash out period before a base-line test is taken.

Then all participants would have to be infused with low, medium and high doses of chlorite (where "high" is roughly equal to NP001-regimen and we'd have to use your esimates to establish what low and mid is). Needless to say we would have to figure how long these treatments should be and there may (or may not) have to be wash-out periods between these before increasing it from low to mid, etc..

After that the calibration model may established and subsequently interpreted to identify which one out of the original broader spectrum of oxidative indices used that are most significantly and dose-dependently linked to the chlorite exposure.

The smaller number of so qualified indices of oxidation is subsequently used to establish the final model.

In the second phase that model may be used to roughly predict the oxidative index (corresponding to arbitrary NP001 dose/exposure units) for someone who has; a) gone through a wash-out period and taken a base line test and thereafter b) consumed a certain amount of OSC during a predetermined period and taken a second test (containing the qualified indices).



People aiming to use the model would have to take two blood samples and submit the results. The cost is depending on the number and the identity of the qualified predictor indices.



I would expect that an antioxidant wash-out period and base-line test may be required, per above.



They would need professional assistance to draw blood and perform the blood works. But the results could be submitted anonymously in a web form and the results displayed in a simple graph.

The risks are obviously that there could be errors in any of these (manual) steps, plus of course possibly also that the model isn't general enough.

This means that there is a possibility that a broader set of blood-work parameters may routinely have to be used in order to determine if a particular subject is sufficiently similar to the multivariate diagnostic domain spanned by model, so that appropriate warnings may be provided in case an "outlier" is using the model.

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Don't just ask what scientists can do to speed up the solution for ALS or when they will do it, instead ask yourself what you can do right now to solve ALS asap.

Hi all,
This is probably not the right place to post this.
I just recieved word that Jan Mulder, aka De Laval, passed away 8 th of may.
We shared a lot of common interest, sodium chlorite esspecially.
I know he read everything here and put it on the dutch forum.
His english was not perfect but he had you all in high regard.
Thanks
Hans

I am very sorry to hear such sad news.

Oh no, how sad. Peace be with you De Laval.

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http://borreliawenttofar.wordpress.com