Finding Cures for ALS

Our unique and comprehensive approach leverages industry experience and a nonprofit mission - focused 100% on ALS research.

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Diagnosed with ALS? Enroll in the Precision Medicine Program here!

 

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Our Research Strategy

We are the world's foremost drug discovery center focused solely on ALS. Pioneering the ‘nonprofit biotech’ model, we have placed the person with ALS at the center of every decision made in our labs.

With preclinical, clinical, and translational research all happening under our one roof, we rapidly pursue the best ideas for slowing, stopping, and ending ALS. We will not stop until there is a treatment for every person living with ALS.

WE OPERATE ONE OF THE LARGEST PRECLINICAL DRUG VALIDATION PROGRAMS IN ALS.

There are too few potential treatments in clinical trials for ALS. We need a robust, good quality drug pipeline to ultimately treat every person living with ALS. More treatments mean more hope.

WE VALIDATE MORE MODELS OF ALS TO ALLOW FOR RIGOROUS TESTING.

ALS is extremely complex involving a myriad of biological pathways. To test drugs more rigorously, we need a variety of both cell and animal models to capture all of the complexities of ALS.

WE AIM TO IMPROVE HOW ALS CLINICAL TRIALS ARE RUN.

Clinical trials for ALS currently require too many participants. That slows the studies down and makes them very costly. Using emerging technologies, we hope to make clinical trials more efficient to reveal the most promising treatments faster.

WE LEARN ABOUT ALS FROM PEOPLE LIVING WITH ALS.

In recent years, we've learned a lot about ALS, but there is still much that we don't know. We believe that best way to learn more is to partner with people living with ALS. Through our Precision Medicine Program, we combine medical histories, family histories, genetics, biomarkers, and patient cell biology to better understand the processes that drive and influence ALS.

Our Achievements

Since its incorporation, ALS TDI has seen major expansion of all our research programs, making progress toward our mission to end ALS.

Our Pipeline

ALS is a complex disease with many different parts of a person's body and biology playing a role in either its onset or progression. We believe that this requires us to explore a robust pipeline of potential treatments at the same time in our labs. This pipeline provides a glimpse into the current potential treatments we are working on, why we are looking at them and where they are in the process. Click on an item (ex TDI-111) on the graphic to learn more about individual projects.

Oxidative Stress

Myelination

 

We take our open-door philosophy and commitment to transparency very seriously. And, we love to show off!

 

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You are needed in the first ever integrated precision medicine effort to end ALS!

This program seeks to gain critical new insight into the discovery and clinical development of treatments for ALS through the integration of genomic, molecular, and patient reported data.

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Favorable Mentions

In my opinion, the research ALS TDI is doing will bring us closer to a cure than anything else going on.

We have met the people who work at ALS TDI and their passion shines through, their personal connections to this disease drive them. We believe they are one of the most progressive and effective insitutes around, and they will be part of the cure.

Jose supported ALS TDI because "of the Institute's single-minded focus on finding a solution for ALS, and doing so as a nonprofit biotech company with top-tier talent. Clear Objective + Solid Strategy + Stellar People = Desired Results."

TDI 208 TDI 209 TDI 168 Unfolded Protein Response TDI 201 TDI 207 TDI 197 TDI 210 TDI 163 TDI 104 TDI 142 SOD1 TDI 200 TDI 186 Neuromuscular Junction TDI 206 TDI 211 Immune Modulation TDI 202 TDI 28 TDI 132 TDI 53 TDI 158