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We Have One Mission:
To End ALS
Founded by the ALS community and fueled by your support – the ALS Therapy Development Institute (ALS TDI) is the world's largest drug discovery lab focused solely on ending ALS.
Founded by the ALS community and fueled by your support – the ALS Therapy Development Institute (ALS TDI) is the world's largest drug discovery lab focused solely on ending ALS.
Donate to Fund Research
We are the Drug Discovery Engine for ALS
We will need many treatments to end ALS. At the ALS Therapy Development Institute (ALS TDI), we are not just advancing one treatment option – we are forging a path to deliver the multiple treatments that will end ALS for every person affected.
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Relentless ALS Research
For the vast majority of people with ALS, there are no effective treatments. At ALS TDI, our dedicated researchers are relentlessly working to change that.
Our scientists work around the clock to discover and develop ALS treatments and advance them to clinical trials.
View our pipeline
Our Relentless Research
Join our ALS study
Informed by Your Experiences
Every case of ALS is unique, and your story matters. Join the ALS Research Collaborative (ARC) study to share your unique experiences and make a meaningful impact in ALS research.
ARC data has already led to significant discoveries in ALS. What breakthroughs could your story help us uncover next?
Join our study
Fueled by Community Support
Fueled by Community Support
We are a 501(c)(3) nonprofit biotech that is solely focused on ALS. Our research is funded by the ALS community – people whose lives have been affected by this disease who are united to end ALS.
We are getting closer to cures, but we need your help.
Help fund treatments
ALS Trial Navigator
Looking for ALS clinical trials? Explore the ALS Trial Navigator – an innovative platform that helps to educate you about current trials and provides personalized recommendations based on your eligibility and preferences. Find ALS trials now!
Find ALS Trials
ALS Trial Navigator
The Latest from ALS TDI
Explore Active ALS TDI Research Programs
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ALS TDI: 2024 Impact Report
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Della Larsen's ALS Story
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Follow ALS Research and Progress
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Community Fundraising Initiatives
Because of our unique nonprofit biotech model, ALS TDI is funded by people with ALS and their friends and families.
Most of our ALS research funding comes from events attended or organized by people like you. Join us!
A Community United to End ALS
Featured Events
Bale Breaker
Jun 28, 2025 Yakima, WA
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Walnut 5K Run/Walk for ALS
Jul 5, 2025 Walnut, IL
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How Can We Improve ALS Diagnosis?
Jul 10, 2025 MA
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Brewing a Cure for ALS Goes Golfing
Jul 19, 2025 Northbridge, MA
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See All Upcoming Events
ALS is not an incurable disease. It is an underfunded one.
You make our critical ALS research possible. Support our mission to end ALS today.
Donate to ALS research
ALS is not an incurable disease. It is an underfunded one.
You make our critical ALS research possible. Support our mission to end ALS today.
Donate to ALS research
Frequently Asked Questions

The ALS Therapy Development Institute (ALS TDI) is a nonprofit biotech, and the world's most comprehensive drug discovery lab focused solely on ALS. Led by drug development experts and people with ALS, our Watertown, Massachusetts-based labs are funded by a global network of supporters unified to end ALS. Our mission is to discover and invent effective treatments for ALS.

The ALS Therapy Development Institute (ALS TDI) is the Drug Discovery Engine for ALS – we work relentlessly to discover and invent ALS treatments in our labs and advance them into clinical trials. ALS TDI incorporates all aspects of drug discovery under one roof to find treatments as quickly as possible.
Our relentless research to find treatments is informed by our ALS Research Collaborative (ARC) – a global initiative to accelerate ALS research by gathering comprehensive data from people with ALS and sharing it with researchers around the world.

There are many ways to support ALS TDI. The simplest is to make a donation or participate in one of our fundraising events. You can organize your own fundraiser with our own fundraising platform or on Facebook. You can even simply share our story and mission with your friends and family, and let them know why you support our work to end ALS. If you are a person with ALS, you can accelerate research by sharing your data through the ALS Research Collaborative (ARC).
FAQs
Fernando
“Many of us at ALS TDI, myself included, have grieved as loved ones have suffered with ALS. So, alongside you, we dedicate our lives to changing the prognosis for this disease.”
– Fernando Vieira, M.D., CEO,
Chief Scientific Officer, and President, ALS TDI
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