Your support fuels our research to #EndALS! Donate Now

The Drug Discovery Engine For ALS

The Drug Discovery
Engine For ALS

Discovering drugs – until all people with ALS have effective treatments

Learn More

Discovering drugs – until all people with ALS have effective treatments

Learn More

Drug Discovery Is What Will End ALS

The treatments in the current clinical pipeline may slow ALS for some, but they will not be enough to end ALS.

We need to discover many more treatments.

The ALS Therapy Development Institute (ALS TDI) is the largest drug discovery lab in the world focused solely on finding treatments for ALS.

Help Us Advance Drug Discovery

Can We Help You Find What You Need?

This is Your Lab

As you read this, our team of researchers and scientists are urgently working in our Boston-area lab – screening drugs, studying animal models, and collecting and analyzing data from people with ALS. The complexity of this disease is staggering, but we are relentless. We will not stop until we have treatments for everyone living with ALS.

“I support ALS TDI because not only is their focus on ALS research and finding a treatment, but ALS TDI focuses on the ALS community, those actually living with the disease. ALS TDI understands the urgency that people with ALS live with in finding a treatment and is driven by that urgency.”

- Jenny Dwyer, Member of the Board of ALS TDI, wife of Pat Dwyer, diagnosed with ALS in 2005 and passed away in 2013

“ALS TDI is one of the world's most transformative medical research institutes focused on ALS. We have applied business principles with the leadership of Dr. Fernando Vieira to find a cure for ALS! I am proud to lead that effort as its Chairman.”

- Augie Nieto, Chairman of the Board of ALS TDI, living with ALS since 2005

Latest ALS Research News

Wednesday, June 15, 2022

A Letter from Our CEO on Tegoprubart

Tuesday, May 31, 2022

Eledon Announces Phase 2a Trial Results for Tegoprubart - a Drug Invented at ALS TDI

Tuesday, April 5, 2022

You Did This! ALS Community Powers ALS TDI and Google's Development of Digital Tools to Measure ALS Progression.

Monday, March 28, 2022

Research Recap Quarter 1 2022

Wednesday, June 15, 2022

A Letter from Our CEO on Tegoprubart

Tuesday, May 31, 2022

Eledon Announces Phase 2a Trial Results for Tegoprubart - a Drug Invented at ALS TDI

Tuesday, April 5, 2022

You Did This! ALS Community Powers ALS TDI and Google's Development of Digital Tools to Measure ALS Progression.

Monday, March 28, 2022

Research Recap Quarter 1 2022

More ALS Research News

Relentless Research

At the ALS Therapy Development Institute (ALS TDI) our sole mission is to discover and develop treatments for amyotrophic lateral sclerosis (ALS) as quickly as possible. ALS TDI is the most comprehensive drug discovery lab dedicated to ALS research. As one of the world's only nonprofit biotech companies, we are led by drug development experts and people with ALS.

ALS Research

Fueled By the Community

As a nonprofit, we are only answerable to our supporters, the ALS community. Our research is funded by the ALS community, a global network of supporters whose lives have been affected by this disease, and who are unified to end ALS. We're getting closer, but we need your help.

Help Fund Treatments

Making An Impact

Our scientific team created tegoprubart, a potential treatment for ALS that is now in clinical trials. We've also pioneered the first ALS Precision Medicine Program to help identify more potential treatments faster. Our team is working on an urgent basis to identify more potential treatments and make them available to people living with ALS.

About Our Work