ALS Clinical Trials | ALS Therapy Development Institute

Your participation in an ALS clinical trial provides researchers with the data they need to determine whether or not a potential treatment is safe and effective, and ultimately, whether or not it should be available as a medication to all those with ALS. The ALS Therapy Development Institute is unbiased in our listing of clinical trials and provides information on all those enrolling worldwide.

We encourage you to browse trials below and subscribe to our clinical trials email to receive monthly updates with changes to trials listed in this database.

Currently Enrolling Clinical Trials

List includes only interventional trials with locations in the US.

Study of ANX005 in Adults With Amyotrophic Lateral Sclerosis (ALS)

Phase 2 - Not Yet Recruiting

Enrollment: 24

Drug: Unknown

Type: Interventional

Open Label: No

Countries: US

Learn More

A Single-Center, Open Label Study to Assess the Safety and Tolerability of Metformin in Subjects With C9orf72 Amyotrophic Lateral Sclerosis Over 24 Weeks of Treatment

Phase 2 - Recruiting

Enrollment: 18

Drug: Single group assignment

Type: Interventional

Open Label: Unknown

Countries: US

Learn More

A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Disease

Phase 2 - Recruiting

Enrollment: 80

Drug: Multi Dose

Type: Interventional

Open Label: Unknown

Countries: US

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An Efficacy and Safety Study of Ravulizumab in ALS Participants

Phase 3 - Recruiting

Enrollment: 354

Drug: Intravenous Infusion

Type: Interventional

Open Label: Yes

Countries: Australia, CA, Denmark, France, Italy, Japan, Netherlands, Poland, Spain, Sweden, Switzerland, United Kingdom, US

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HEALEY ALS Platform Trial - Master Protocol

Phase 2/ 3 - Recruiting

Enrollment: 480

Drug: Multiple

Type: Interventional

Open Label: Yes

Countries: US

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Therapy in Amyotrophic Lateral Sclerosis With Memantine at 20 mg BID (TAME)

Phase 2 - Recruiting

Enrollment: 90

Drug: Orally available by tablet

Type: Interventional

Open Label: Unknown

Countries: US

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An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS)

Phase 3 - Recruiting

Enrollment: 183

Drug: Single and Multiple Ascending Dose

Type: Interventional

Open Label: Yes

Countries: Australia, Belgium, CA, Denmark, France, Germany, Italy, Japan, Other, United Kingdom, US

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MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)

Phase 2 - Recruiting

Enrollment: 228

Drug: Unknown

Type: Interventional

Open Label: Yes

Countries: US

Learn More

Study of ANX005 in Adults With Amyotrophic Lateral Sclerosis (ALS)

Phase 2 - Not Yet Recruiting

Enrollment: 24

Drug: Unknown

Type: Interventional

Open Label: No

Countries: US

Learn More

A Single-Center, Open Label Study to Assess the Safety and Tolerability of Metformin in Subjects With C9orf72 Amyotrophic Lateral Sclerosis Over 24 Weeks of Treatment

Phase 2 - Recruiting

Enrollment: 18

Drug: Single group assignment

Type: Interventional

Open Label: Unknown

Countries: US

Learn More

A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Disease

Phase 2 - Recruiting

Enrollment: 80

Drug: Multi Dose

Type: Interventional

Open Label: Unknown

Countries: US

Learn More

An Efficacy and Safety Study of Ravulizumab in ALS Participants

Phase 3 - Recruiting

Enrollment: 354

Drug: Intravenous Infusion

Type: Interventional

Open Label: Yes

Countries: Australia, CA, Denmark, France, Italy, Japan, Netherlands, Poland, Spain, Sweden, Switzerland, United Kingdom, US

Learn More

HEALEY ALS Platform Trial - Master Protocol

Phase 2/ 3 - Recruiting

Enrollment: 480

Drug: Multiple

Type: Interventional

Open Label: Yes

Countries: US

Learn More

Therapy in Amyotrophic Lateral Sclerosis With Memantine at 20 mg BID (TAME)

Phase 2 - Recruiting

Enrollment: 90

Drug: Orally available by tablet

Type: Interventional

Open Label: Unknown

Countries: US

Learn More

An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS)

Phase 3 - Recruiting

Enrollment: 183

Drug: Single and Multiple Ascending Dose

Type: Interventional

Open Label: Yes

Countries: Australia, Belgium, CA, Denmark, France, Germany, Italy, Japan, Other, United Kingdom, US

Learn More

MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)

Phase 2 - Recruiting

Enrollment: 228

Drug: Unknown

Type: Interventional

Open Label: Yes

Countries: US

Learn More

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Articles About Clinical Trials

Wednesday, August 19, 2020

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Currently Enrolling Clinical Trials

Study of ANX005 in Adults With Amyotrophic Lateral Sclerosis (ALS)

A Single-Center, Open Label Study to Assess the Safety and Tolerability of Metformin in Subjects With C9orf72 Amyotrophic Lateral Sclerosis Over 24 Weeks of Treatment

A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Disease

An Efficacy and Safety Study of Ravulizumab in ALS Participants

HEALEY ALS Platform Trial - Master Protocol

Therapy in Amyotrophic Lateral Sclerosis With Memantine at 20 mg BID (TAME)

An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS)

MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)

Study of ANX005 in Adults With Amyotrophic Lateral Sclerosis (ALS)

A Single-Center, Open Label Study to Assess the Safety and Tolerability of Metformin in Subjects With C9orf72 Amyotrophic Lateral Sclerosis Over 24 Weeks of Treatment

A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Disease

An Efficacy and Safety Study of Ravulizumab in ALS Participants

HEALEY ALS Platform Trial - Master Protocol

Therapy in Amyotrophic Lateral Sclerosis With Memantine at 20 mg BID (TAME)

An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS)

MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)

Search All Active Clinical Trials

Articles About Clinical Trials

How I Used the Precision Medicine Program to Measure my Disease Progression During an ALS Clinical Trial

Why COVID-19 Treatments May be Coming in Months, While ALS Research Takes Years

The Clinical Trial Process | The Four Phases Explained

FDA Issues Guidance Document for ALS Clinical Trials