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Did an Israeli Company Developed a Cure for ALS?

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Fafut_1		Posted: Monday, July 23, 2012 3:06:39 AM
Rank: Advanced Member Groups: Member Joined: 8/23/2010 Posts: 728 Location: Poland		5 yrs from now....unless u r rabbi. I wonder - if it really works, still 5 yrs ??????????
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ichisan		Posted: Monday, July 23, 2012 3:16:18 AM
Rank: Advanced Member Groups: Member Joined: 12/4/2011 Posts: 1,518 Location: United States		Fafut_1 wrote: 5 yrs from now....unless u r rabbi. I wonder - if it really works, still 5 yrs ?????????? In my opinion, they should not wait for FDA approval to begin providing treatments to whomever can afford it. They should beat Dr. Williams at his own game by licensing their Nurown technology to independent clinics around the world. Or is that the other way around? Louis
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DeeBee		Posted: Monday, July 23, 2012 3:41:30 AM
Rank: Advanced Member Groups: Member Joined: 7/23/2009 Posts: 2,347 Location: United Kingdom		ichisan wrote: Brainstorm in the news: Israel adult stem cell trials - hope for ALS patients? By Tova Cohen TEL AVIV \| Mon Jul 23, 2012 12:32am EDT (Reuters) - A clinical trial of ALS patients conducted by BrainStorm Cell Therapeutics shows its adult stem cell therapy is well-tolerated, appears to be safe and does not present undue risk, according to an interim safety review. Moreover, in some patients signs of stabilization of the disease were detected. Israel-based BrainStorm is developing NurOwn for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's Disease, a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. "It's very uncommon to give at such an early point in a clinical study efficacy data, but we cannot ignore the fact on an individual basis we could see improvement in many of the patients involved, each one in different areas," Moshe Neuman, CEO of Biomedical Research Design, which serves as a contract research organization for the trial, said. In some patients breathing improved, in others it was muscle strength and in others it was speech, he told Reuters. Neuman said a final report was expected by the end of the year after each patient has been observed for nine months. Read more... It has been said many times before, but they don't mention 'significantly improved EMG' readings etc.... They are talking about 'perceived improvement' only.
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Fafut_1		Posted: Monday, July 23, 2012 8:14:17 AM
Rank: Advanced Member Groups: Member Joined: 8/23/2010 Posts: 728 Location: Poland		EMG is a bad tool. what it mainly shows are fibrillations and fascics which can be seen even if nerves recover/ I'm not sure if it can distinguish whether the muscle is more or less innervated...I would say the strength amd endurance test is better. BTW - it is so pathetic that we aresupposed to base on EMG findings which is few decades old...
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DeeBee		Posted: Monday, July 23, 2012 8:50:53 AM
Rank: Advanced Member Groups: Member Joined: 7/23/2009 Posts: 2,347 Location: United Kingdom		EMG is described as an important test by the MNDA.......... 'Electromyography (EMG): is sometimes called the needle test, because fine needles are used to record the naturally-occurring nerve impulses within certain muscles. Recordings are usually taken from each limb and the bulbar (throat) muscles. Muscles, which have lost their nerve supply, can be detected because their electrical activity is different from normal healthy muscles. The EMG can be shown as abnormal even if that particular muscle is as yet unaffected. It is a very important diagnostic test.' EMG can show 'improvements' on re-test, IIRC. ( Perceptions of strength and endurance can be colored by emotion, that's why so many patients reported great effects from lithium which in reality was doing nothing ).
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senso42		Posted: Monday, July 23, 2012 11:00:07 AM
Rank: Advanced Member Groups: Member Joined: 4/5/2012 Posts: 271 Location: France		deebee i disagree with mnda, emg is a simply "by default" test. anomalies are detected only in advanced cases of the disease.
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RL Schafferr		Posted: Monday, July 23, 2012 11:17:13 AM
Rank: Advanced Member Groups: Member Joined: 6/14/2009 Posts: 6,051 Location: Inman ,S.C. USA		I've had 5 emgs dee dee. One at mayo,, one at duke, 3 at different Neuros. All showed normal or not enough to diagnose. And I've had ALS for 9 years. Who knows better? MNDA doesn't , for sure.
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DeeBee		Posted: Monday, July 23, 2012 11:57:12 AM
Rank: Advanced Member Groups: Member Joined: 7/23/2009 Posts: 2,347 Location: United Kingdom		I'll tell the MNDA to chuck their EMG machine out of the window immediately.
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Fafut_1		Posted: Monday, July 23, 2012 12:11:56 PM
Rank: Advanced Member Groups: Member Joined: 8/23/2010 Posts: 728 Location: Poland		Dr Rutkove earned 1M$ for "great new tool" but....where is it?
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DeeBee		Posted: Monday, July 23, 2012 12:26:15 PM
Rank: Advanced Member Groups: Member Joined: 7/23/2009 Posts: 2,347 Location: United Kingdom		Fafut_1 wrote: Dr Rutkove earned 1M$ for "great new tool" but....where is it? Here it is......... http://www.youtube.com/watch?v=Za4dzqDRDho&feature=related
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lab867		Posted: Monday, July 23, 2012 5:53:51 PM
Rank: Advanced Member Groups: Member Joined: 4/19/2010 Posts: 247 Location: United States		Fafut_1 wrote: Dr Rutkove earned 1M$ for "great new tool" but....where is it? If you want to follow the progress of the machine getting out into the marketplace looks like they are willing to keep you informed if you want to sign up: http://cmdevices.com/contact I think its being used in the Neuralstem trial, but I'm not aware of any other trials in which its being used.
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HappyPhysicist		Posted: Tuesday, July 24, 2012 12:46:14 PM
Rank: Advanced Member Groups: Member Joined: 4/20/2011 Posts: 870 Location: United States		The real test for any treatment is how long it lasts, the following quote will likely also be made by Neuraltus when they announce their phase II results: Quote: It's very uncommon to give at such an early point in a clinical study efficacy data, but we cannot ignore the fact on an individual basis we could see improvement in many of the patients involved, each one in different areas. But if the experience from Sodium Chlorite is an indication of NP001's long term effectiveness then it won't be the miracle it at first seemed to be. Moreover, given Ted Herada's posts about how he seems to be progressing again, chances are the subjects in this study will also see only a temporary relief of their progression. Funny isn't it. I was the eternal optimist, now I'm the one asking people not to be too optimistic. If it is done in secret, it is done in vain.
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senso42		Posted: Tuesday, July 24, 2012 12:53:50 PM
Rank: Advanced Member Groups: Member Joined: 4/5/2012 Posts: 271 Location: France		DeeBee wrote: I'll tell the MNDA to chuck their EMG machine out of the window immediately. lol
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senso42		Posted: Tuesday, July 24, 2012 1:00:09 PM
Rank: Advanced Member Groups: Member Joined: 4/5/2012 Posts: 271 Location: France		HappyPhysicist wrote: The real test for any treatment is how long it lasts, the following quote will likely also be made by Neuraltus when they announce their phase II results: But if the experience from Sodium Chlorite is an indication of NP001's long term effectiveness then it won't be the miracle it at first seemed to be. Moreover, given Ted Herada's posts about how he seems to be progressing again, chances are the subjects in this study will also see only a temporary relief of their progression. Funny isn't it. I was the eternal optimist, now I'm the one asking people not to be too optimistic. in one video, we can see the director of brainstorm saying that they think that it would take 3 injections per year to stabilize patients. So it' s not a cure but a treatment with a big potential
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Fafut_1		Posted: Tuesday, July 24, 2012 1:08:54 PM
Rank: Advanced Member Groups: Member Joined: 8/23/2010 Posts: 728 Location: Poland		surely ALS will require permanent treatment....like diabetes. I wouldnt count on permanent reversal. Now the case is to establish intevals and dosing (assuming that one works)
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ichisan		Posted: Tuesday, July 24, 2012 3:31:08 PM
Rank: Advanced Member Groups: Member Joined: 12/4/2011 Posts: 1,518 Location: United States		Here's your chance to get your Brainstorm questions answered: NEW YORK & PETACH TIKVAH, Israel--(BUSINESS WIRE)-- BrainStorm Cell Therapeutics Inc. (BCLI), a leading developer of adult stem cell technologies and therapeutics, announced today that its senior management will hold a conference call on Wednesday, July 25, 2012 at 8:00 a.m. EDT in Hebrew and at 8:45 a.m. EDT in English. Dr. Adrian Harel, Chief Executive Officer, Mr. Chaim Lebovits, President, Ms. Liat Sossover, Chief Financial Officer, and Prof. Daniel Offen, PhD, Chief Scientific Advisor, will discuss the results of the Company’s recent interim safety report and other developments. Callers may participate in the conference call by dialing: USA: 1-888-407-2553 Israel: 1-800-227-297 (Hebrew at 08:00 a.m. EDT), or 1-800-270-345 (English at 08:45 a.m. EDT). International: +972-3-918-0664 Callers are invited to ask relevant questions during the conference call. Questions may also be pre-submitted to info@brainstorm-cell.com prior to 7:00 a.m. EDT on Wednesday, July 25, 2012. A recording of the conference will be available for download Monday, July 30, 2012 from the company’s website at the following link: http://bit.ly/OVVV6F. Louis PS. I'm surprised that Brainstorm's shares went down to $0.27 a share after the recent announcement that the safety trial was successful. I guess that everyone already knew what they were going to say.
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OhGosh		Posted: Tuesday, July 24, 2012 4:34:15 PM
Rank: Advanced Member Groups: Member Joined: 12/9/2010 Posts: 179 Location: United States		HP: I saw your comments about Neuraluts and OSC. Would you say the same thing about the use of Nuedexta or DM (that the initial excitement might wane)? I saw the threads on them only couple of days ago, upset I did not see it before and trying to see if my non-cooperative young PALS would take it. Also, regarding EMG, let me add my few cents as a university, NSF researcher with 30 years of experience in these areas (known as signal processing and signal understanding). I do not trust the results given all the complexities involved and the ability (or the lack of it) of the people using them. It has become a money making machine (like buy a EKG and use it every year on each patient etc.). If it is such a gold standard, they don't need to insist that they got to do it themselves (even if done by another equally good neurologist only recently). I am getting pulled down and begun to accept all as fate. Forget the medicines and treatments!
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Entity		Posted: Tuesday, July 24, 2012 7:09:02 PM
Rank: Member Groups: Member Joined: 2/26/2012 Posts: 25 Location: Canada - ON		HappyPhysicist wrote: Moreover, given Ted Herada's posts about how he seems to be progressing again, chances are the subjects in this study will also see only a temporary relief of their progression. HP, where can we find Ted Harada's posts about his returning progression? Thanks.
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RL Schafferr		Posted: Tuesday, July 24, 2012 10:05:07 PM
Rank: Advanced Member Groups: Member Joined: 6/14/2009 Posts: 6,051 Location: Inman ,S.C. USA		OhGosh wrote: HP: I saw your comments about Neuraluts and OSC. Would you say the same thing about the use of Nuedexta or DM (that the initial excitement might wane)? I saw the threads on them only couple of days ago, upset I did not see it before and trying to see if my non-cooperative young PALS would take it. Also, regarding EMG, let me add my few cents as a university, NSF researcher with 30 years of experience in these areas (known as signal processing and signal understanding). I do not trust the results given all the complexities involved and the ability (or the lack of it) of the people using them. It has become a money making machine (like buy a EKG and use it every year on each patient etc.). If it is such a gold standard, they don't need to insist that they got to do it themselves (even if done by another equally good neurologist only recently). I am getting pulled down and begun to accept all as fate. Forget the medicines and treatments! Wise !! U are learning .. Thanks for Posting. People swear by the damn things and they ain't worth a damn. Whos giving them is verrrrrruyyyyimportant.
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MattJ		Posted: Wednesday, July 25, 2012 7:46:00 AM
Rank: Advanced Member Groups: Member Joined: 7/14/2011 Posts: 72 Location: United Kingdom		Here is Teds post: http://www.alsforums.com/forum/als-research-news/19573-update-neuralstem-trial-2.html#post240118
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