The purpose of this study is to assess the effect of reldesemtiv versus placebo on functional outcomes in ALS.
COURAGE-ALS is a Phase 3, double-blind, randomized, placebo-controlled trial of reldesemtiv in patients aged 18 to 80 with ALS. The screening and qualification period for the trial will be no more than 14 days in duration. Approximately 555 eligible ALS patients will be randomized (2:1) to receive the following dose of reldesemtiv or placebo (stratified by riluzole use/non-use and edaravone use/non-use) for the first 24 weeks (double-blind, placebo-controlled period): - 300 mg reldesemtiv twice a day for a 600 mg total daily dose (TDD) - Placebo twice daily At the end of the 24-week double-blind, placebo-controlled period, patients will transition to the active drug period, where all patients will receive the following dose of reldesemtiv for the next 24 weeks: - 300 mg reldesemtiv twice a day for a 600 mg TDD for patients who were not down titrated during the 24 weeks of blinded dosing - 150 mg reldesemtiv twice a day for a 300 mg TDD for patients who were down titrated during the 24 weeks of blinded dosing
Key Inclusion Criteria:
- Males or Females between the ages of 18 and 80 years of age, inclusive
- Diagnosis of familial or sporadic ALS (defined as meeting the laboratory-supported
probable, probable, or definite criteria for ALS according to the World Federation of
Neurology El Escorial criteria). Patients who meet the possible criteria are eligible
if they have lower motor neuron findings; those who have purely upper motor neuron
findings are ineligible.
- First symptom of ALS ≤ 24 months prior to screening. The qualifying first symptoms of
ALS are limited to manifestations of weakness in extremity, bulbar, or respiratory
muscles.
- ALSFRS-R total score ≤ 44 at screening. Patients with a total score of 45 or higher
may be rescreened 60±7 days following the original screening date.
- Upright FVC ≥ 65.0% of predicted for age, height, sex and ethnicity at screening
according to Global Lung Initiative equation
- Must be either on riluzole for ≥ 30 days prior to screening or have not taken it for
at least 30 days prior to screening
- Must have completed at least 2 cycles of edaravone at the time of screening or have
not received it for at least 30 days prior to screening
- Able to swallow whole tablets
Exclusion Criteria:
- eGFRCysC < 45.0 mL/min/1.73 m2 at screening
- Urine protein/creatinine ratio > 1 mg/mg (113 mg/mmol) at screening
- Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥ 3-times the upper
limit of normal (ULN)
- Total bilirubin (TBL), direct or indirect bilirubin above the ULN.
- Cognitive impairment, related to ALS or otherwise that impairs the patient's ability
to understand and/or comply with study procedures and provide informed consent
- Other medically significant neurological conditions that could interfere with the
assessment of ALS symptoms, signs or progression.
- Has a tracheostomy