Interventional {{label}}

Clinical Trial Ceftriaxone in Subjects With ALS

Please note: All trial information reflects the latest data available from the sponsor on ClinicalTrials.gov and other public databases. However, these sources may occasionally be outdated or inaccurate. For the most current information, we recommend contacting the trial sponsor or sites directly.

Overview

Intervention or Drug Name

Sponsor

Trial Status

Phase

Randomization

Trial Duration

Route of Administration

Genetic Target

Repurposed Drugs

Approved by FDA

Approved outside USA

Is a supplement

Details

Enrollment Criteria

Time since symptom onset

Vital Capacity (FVC or SVC)

Approved Medications

Registry Listing

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Purpose

The purpose of the study is to evaluate the safety and efficacy of ceftriaxone treatment in amyotrophic lateral sclerosis (ALS).

What participation looks like

Participants will be randomly assigned to receive treatment with ceftriaxone or placebo for at least 12 months. Two thirds of participants will receive ceftriaxone and one third will receive placebo. This is a blinded study, so neither participants nor study staff will know which treatment a participant is receiving.

Ceftriaxone is being studied based on the idea that it is an antiglutamatergic. There have been preclinical in vivo studies conducted that have shown a positive effect in SOD1 mice. Data from the Phase I/II trial was presented at the 2009 ALS/MND Meeting in Berlin, Germany that showed the drug was safe and tolerated in ALS patients.

Eligibility criteria

18 years and older. Both Genders. No healthy volunteers.

Locations

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