The NeuRX Diaphragm Pacing System. Image: Synapse Biomedical.

Researchers in the UK will soon be putting the NeuRX diaphragm pacing system (DPS) to the test to determine whether the device in combination with non-invasive ventilation (NIV) improves the quality of life and extends survival of people with ALS experiencing respiratory weakness. The clinical trial, known as Diaphragm Pacing In Motor Neuron Disease (DiPALS), will be conducted at up to 10 National Health Service (NHS) hospitals in the UK. Trial participants will receive either NIV or NIV and be implanted with the NeuRX DPS.  108 people with ALS are expected to enroll.  The trial is expected to be completed in 2014.

To read more about the NeuRx diaphragm pacer and how the device might benefit people with ALS, read our recent feature DPS Sleep.

Further Reading

Scherer, K. and Bedlack, R.S (2012) Diaphragm pacing in amyotrophic lateral sclerosis: a literature review. Muscle and Nerve 46(1), 1-8. Abstract Full Text (Subscription Required)

Marion, D.W. (2011) Diaphragm Pacing. UpToDate.  Excerpt  Full Text (Subscription Required)  

Patient Resources

Diaphragm Pacing in Motor Neuron Disease (DiPALS) Study  Contact | ALS TDI  |  Website 

Update 1/25/13: The trial is now ongoing.  At least 7 sites in the UK are recruiting people with ALS MND including the Royal Free Hospital in London and the John Radcliffe Hospital in Oxford.