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Riluzole may protect motor nerves from further deterioration by reducing glutamate levels in the brain and spinal cord by blocking its release from nerve terminals.


Type: Small Molecule
Stage: FDA-Approved
Status: FDA-Approved

TDI Says:

Although it only has modest effects on disease progression, riluzole is the only FDA-approved drug for ALS.

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  • Postcard from Australia

    Neuroscience Research Australia’s Steve Vucic PhD discusses emerging combination treatment strategies including riluzole that may reduce hyperexcitability, a potential early step in the disease.

Published Results

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